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Literature summary extracted from

  • Solling, H.; Esmann, V.
    Purification and properties of glycogen synthase I from human leukocytes (1977), Eur. J. Biochem., 81, 119-128.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Homo sapiens

General Stability

EC Number General Stability Organism
2.4.1.11 albumin is essential during lyophilization, lyophilized enzyme is stable for years Homo sapiens
2.4.1.11 dithiothreitol stabilizes Homo sapiens
2.4.1.11 glucose 6-phosphate stabilizes Homo sapiens
2.4.1.11 glycogen stabilizes Homo sapiens
2.4.1.11 phosphate stabilizes Homo sapiens
2.4.1.11 spontaneous, temperature-dependent inactivation caused by irreversible conformational changes Homo sapiens
2.4.1.11 sulfate stabilizes Homo sapiens
2.4.1.11 UDP stabilizes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.11 2-mercaptoethanol high concentrations Homo sapiens
2.4.1.11 ATP
-
Homo sapiens
2.4.1.11 dithiothreitol high concentrations Homo sapiens
2.4.1.11 ethanol traces inactivate the enzyme Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.11 390000
-
sucrose density gradient centrifugation Homo sapiens
2.4.1.11 410000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Homo sapiens
-
glycogen + UDP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 leukocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.11 21
-
synthase I Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.4.1.11 -20°C, glycogen-free or glycogen-containing enzyme, lyophilized, more than 3 years, solubilized enzyme several weeks Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
Homo sapiens glycogen + UDP
-
?

Subunits

EC Number Subunits Comment Organism
2.4.1.11 ? x * 80000-85000, SDS-PAGE Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.11 37
-
-
Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.1.11 37
-
inactivation in a few h Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.11 6.8 9.2 synthase I, presence of glucose 6-phosphate Homo sapiens
2.4.1.11 7.2 8 synthase I, absence of glucose 6-phosphate Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.1.11 6.8 7.6
-
Homo sapiens
2.4.1.11 7.4 8.4 sensitive to small changes in pH in the presence of Mg2+ Homo sapiens