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Literature summary extracted from

  • Mitchell, J.W.; Thomas, J.A.
    Phosphorylation of bovine heart glycogen synthase by two protein kinases. Kinetic properties of phosphorylated forms of the enzyme (1981), J. Biol. Chem., 256, 6160-6169.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Bos taurus
2.4.1.11 SO42- stimulatory effect increases as the enzyme becomes more phosphorylated Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.11 additional information
-
 additional information values for phosphorylated enzyme forms Bos taurus
2.4.1.11 0.9
-
 UDP-glucose
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Bos taurus
-
 glycogen + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.11 phosphoprotein phosphorylation of glucose-6-phosphate independent enzyme, i.e. I enzyme, results in glucose-6-phosphate dependent enzyme, i.e. D enzyme Bos taurus
2.4.1.11 phosphoprotein phosphorylation leads to loss of activity Bos taurus
2.4.1.11 phosphoprotein incorporation of 1-3 phosphates per subunit Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 heart
-
 Bos taurus
-

Storage Stability

EC Number Storage Stability Organism
2.4.1.11 -70°C, stable for at least 3 months Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
 Bos taurus glycogen + UDP
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.11 7.8
-
 assay at Bos taurus