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Literature summary extracted from

  • Westphal, S.A.; Nuttall, F.Q.
    Comparative characterization of human and rat liver glycogen synthase (1992), Arch. Biochem. Biophys., 292, 479-486.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Homo sapiens
2.4.1.11 glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.11 additional information
-
 additional information dependence on glucose 6-phosphate concentration Homo sapiens
2.4.1.11 additional information
-
 additional information dependence on glucose 6-phosphate concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen Homo sapiens
-
 glycogen + UDP
-
 ?
2.4.1.11 UDP-glucose + glycogen Rattus norvegicus
-
 glycogen + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Homo sapiens
-
-
-
2.4.1.11 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.11 liver
-
 Homo sapiens
-
2.4.1.11 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.11 40
-
-
 Homo sapiens
2.4.1.11 40
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 UDP-glucose + glycogen
-
 Homo sapiens glycogen + UDP
-
 ?
2.4.1.11 UDP-glucose + glycogen
-
 Rattus norvegicus glycogen + UDP
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.11 30 40
-
 Homo sapiens
2.4.1.11 30 40
-
 Rattus norvegicus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.4.1.11 additional information
-
 human enzyme has no activity above 50°C, rat enzyme is active up to at least 60°C Homo sapiens
2.4.1.11 additional information
-
 human enzyme has no activity above 50°C, rat enzyme is active up to at least 60°C Rattus norvegicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.4.1.11 50
-
 inactivation above Homo sapiens
2.4.1.11 60
-
 inactivation above Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.11 7 9 synthase I Homo sapiens
2.4.1.11 7 9 synthase I Rattus norvegicus
2.4.1.11 8.8
-
 synthase D Homo sapiens
2.4.1.11 8.8
-
 synthase D Rattus norvegicus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.4.1.11 additional information
-
 overview: stability in various buffer systems Homo sapiens
2.4.1.11 additional information
-
 overview: stability in various buffer systems Rattus norvegicus