EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.101 | additional information | no activation by 2-mercaptoethanol | Oryctolagus cuniculus | |
2.4.1.101 | Triton X-100 | - |
Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.101 | 2'-dUDP | weak | Oryctolagus cuniculus | |
2.4.1.101 | 2'-O-Methyl-UDP | weak | Oryctolagus cuniculus | |
2.4.1.101 | 5-Bromo-UTP | - |
Oryctolagus cuniculus | |
2.4.1.101 | 5-Mercury-UDP | - |
Oryctolagus cuniculus | |
2.4.1.101 | alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
Oryctolagus cuniculus | |
2.4.1.101 | additional information | no inhibitors are CDP, UDPhexanolamine, AMP | Oryctolagus cuniculus | |
2.4.1.101 | TDP | - |
Oryctolagus cuniculus | |
2.4.1.101 | UDP | - |
Oryctolagus cuniculus | |
2.4.1.101 | UDP-glucose | weak | Oryctolagus cuniculus | |
2.4.1.101 | UDP-N-acetylgalactosamine | weak | Oryctolagus cuniculus | |
2.4.1.101 | UDP-N-acetylglucosamine | competitively to UDP | Oryctolagus cuniculus | |
2.4.1.101 | UMP | weak | Oryctolagus cuniculus | |
2.4.1.101 | UTP | weak | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.101 | additional information | - |
additional information | kinetic study | Oryctolagus cuniculus | |
2.4.1.101 | 0.0384 | - |
UDP-N-acetyl-D-glucosamine | - |
Oryctolagus cuniculus | |
2.4.1.101 | 0.0384 | - |
alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
Oryctolagus cuniculus | |
2.4.1.101 | 2.03 | - |
alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosamine | - |
Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.101 | membrane | - |
Oryctolagus cuniculus | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.101 | Ba2+ | slight activation | Oryctolagus cuniculus | |
2.4.1.101 | Ca2+ | slight activation | Oryctolagus cuniculus | |
2.4.1.101 | Cd2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Cd2+ | can substitute for Mn2+ with 20% | Oryctolagus cuniculus | |
2.4.1.101 | Co2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Co2+ | can substitute for Mn2+ with 80% | Oryctolagus cuniculus | |
2.4.1.101 | Fe2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Fe2+ | can substitute for Mn2+ with 65% efficiency | Oryctolagus cuniculus | |
2.4.1.101 | Mg2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Mg2+ | can substitute for Mn2+ with 40% | Oryctolagus cuniculus | |
2.4.1.101 | Mn2+ | requirement | Oryctolagus cuniculus | |
2.4.1.101 | additional information | no activation by Cu2+ | Oryctolagus cuniculus | |
2.4.1.101 | additional information | no activation by Sr2+, Pb2+ | Oryctolagus cuniculus | |
2.4.1.101 | Ni2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Ni2+ | can substitute for Mn2+ with 20% | Oryctolagus cuniculus | |
2.4.1.101 | Sn2+ | slight activation | Oryctolagus cuniculus | |
2.4.1.101 | Zn2+ | activation | Oryctolagus cuniculus | |
2.4.1.101 | Zn2+ | can substitute for Mn2+ with 8% | Oryctolagus cuniculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.101 | additional information | - |
separable by gel filtration | Oryctolagus cuniculus |
2.4.1.101 | additional information | - |
two MW-species | Oryctolagus cuniculus |
2.4.1.101 | 45000 | - |
x * 45000 + x * 50000 + x * 54000, low molecular weight form, SDS-PAGE, major band: MW 45000 | Oryctolagus cuniculus |
2.4.1.101 | 50000 | - |
x * 45000 + x * 50000 + x * 54000, low molecular weight form, SDS-PAGE, major band: MW 45000 | Oryctolagus cuniculus |
2.4.1.101 | 54000 | - |
x * 45000 + x * 50000 + x * 54000, low molecular weight form, SDS-PAGE, major band: MW 45000 | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide | Oryctolagus cuniculus | key enzyme of biosynthesis of complex and hybrid N-glycans | UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.101 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.101 | two molecular weight forms separable by gel filtration, purification of low-molecular weight form | Oryctolagus cuniculus |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.4.1.101 | UDP-N-acetyl-alpha-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein] | mechanism | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.101 | liver | - |
Oryctolagus cuniculus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.4.1.101 | 19.8 | - |
low-molecular weight form | Oryctolagus cuniculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.101 | additional information | acts on synthetic substrate analogues | Oryctolagus cuniculus | ? | - |
? | |
2.4.1.101 | additional information | no acceptor substrates are N-acetyl-D-glucosamine, N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn | Oryctolagus cuniculus | ? | - |
? | |
2.4.1.101 | UDP + alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosamine | - |
Oryctolagus cuniculus | ? | - |
? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: H | Oryctolagus cuniculus | UDP + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: H | ? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | 1,4-N-acetyl-D-glucosaminyl-Asn | Oryctolagus cuniculus | UDP + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: H | ? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | synthetic-beta-D-mannosyl-(1,6-anhydro)-derivative acts as substrate, too | Oryctolagus cuniculus | UDP + N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: H | ? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide | key enzyme of biosynthesis of complex and hybrid N-glycans | Oryctolagus cuniculus | UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-Asn-peptide | - |
? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | substrate specificity | Oryctolagus cuniculus | UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: 1,4-N-acetyl-D-glucosaminyl-Asn | ? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | essential for activity: unsubstituted equatorial hydroxyl on C-4 of beta-linked mannosyl-residue | Oryctolagus cuniculus | UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: 1,4-N-acetyl-D-glucosaminyl-Asn | ? | |
2.4.1.101 | UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: 1,4-N-acetyl-D-glucosaminyl-Asn | Oryctolagus cuniculus | UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | R: 1,4-N-acetyl-D-glucosaminyl-Asn | ? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.1.101 | ? | x * 45000 + x * 50000 + x * 54000, low molecular weight form, SDS-PAGE, major band: MW 45000 | Oryctolagus cuniculus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.101 | 37 | - |
assay at | Oryctolagus cuniculus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.101 | 5.6 | - |
- |
Oryctolagus cuniculus |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.101 | 5.1 | 6.9 | about half-maximal activity at pH 5.1 and about 70% of maximal activity at pH 6.9 | Oryctolagus cuniculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.4.1.101 | 0.034 | - |
UDP-N-acetylglucosamine | - |
Oryctolagus cuniculus | |
2.4.1.101 | 1.8 | - |
alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R | - |
Oryctolagus cuniculus |