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Literature summary extracted from

  • Uchiyama, H.; Tabuchi, T.
    Properties of methylcitrate synthase from Candida lipolytica (1976), Agric. Biol. Chem., 40, 1411-1418.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.3.5 isocitrate 1 mM, relative activity 101% Yarrowia lipolytica

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.5 ADP slight inhibition Yarrowia lipolytica
2.3.3.5 ATP
-
Yarrowia lipolytica
2.3.3.5 H2O2
-
Yarrowia lipolytica
2.3.3.5 Hg2+
-
Yarrowia lipolytica
2.3.3.5 Monoiodoacetamide
-
Yarrowia lipolytica
2.3.3.5 NADH
-
Yarrowia lipolytica
2.3.3.5 NADPH
-
Yarrowia lipolytica
2.3.3.5 p-chloromercuribenzoate
-
Yarrowia lipolytica
2.3.3.5 Zn2+
-
Yarrowia lipolytica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.3.5 0.0029
-
acetyl-CoA
-
Yarrowia lipolytica
2.3.3.5 0.0053
-
propionyl-CoA
-
Yarrowia lipolytica
2.3.3.5 0.022
-
butyryl-CoA
-
Yarrowia lipolytica
2.3.3.5 0.025
-
oxaloacetate
-
Yarrowia lipolytica
2.3.3.5 0.025
-
valeryl-CoA
-
Yarrowia lipolytica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.3.5 Ca2+ 1 mM, relative activity 104% Yarrowia lipolytica
2.3.3.5 Fe2+ 0.02 mM, relative activity 104% Yarrowia lipolytica
2.3.3.5 Mg2+ 1 mM, relative activity 102% Yarrowia lipolytica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate Yarrowia lipolytica physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate Escherichia coli first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate Yarrowia lipolytica first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.5 Escherichia coli
-
-
-
2.3.3.5 Yarrowia lipolytica
-
formerly Candida lipolytica
-
2.3.3.5 Yarrowia lipolytica
-
IFO 1659
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.5
-
Yarrowia lipolytica

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.3.5 0.436
-
substrate propionyl-CoA Yarrowia lipolytica
2.3.3.5 0.623
-
substrate acetyl-CoA Yarrowia lipolytica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.5 acetyl-CoA + H2O + oxaloacetate
-
Yarrowia lipolytica citrate + CoA
-
?
2.3.3.5 additional information enzyme is specific for oxaloacetate, does not catalyze liberation of CoA from acetyl- or propionyl-CoA in presence of glyoxylate, pyruvate or alpha-ketoglutarate, isobutyryl-CoA and isovaleryl-CoA are no substrates Yarrowia lipolytica ?
-
?
2.3.3.5 n-butyryl-CoA + H2O + oxaloacetate
-
Yarrowia lipolytica 2-ethylcitrate + CoA
-
r
2.3.3.5 n-valeryl-CoA + H2O + oxaloacetate
-
Yarrowia lipolytica 2-propylcitrate + CoA
-
r
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate
-
Escherichia coli 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate
-
Yarrowia lipolytica 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle Yarrowia lipolytica 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Escherichia coli 2-methylcitrate + CoA
-
?
2.3.3.5 propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Yarrowia lipolytica 2-methylcitrate + CoA
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.3.5 45
-
-
Yarrowia lipolytica

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.3.3.5 10 50
-
Yarrowia lipolytica

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.3.5 50
-
activity completely lost after 10 min Yarrowia lipolytica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.3.5 8 8.5
-
Yarrowia lipolytica

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.3.3.5 6 9.5
-
Yarrowia lipolytica