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Literature summary extracted from

  • Gray, G.S.; Bhattacharjee, J.K.
    Biosynthesis of lysine in Saccharomyces cerevisiae: Regulation of homocitrate synthase in analogue-resistant mutants (1976), J. Gen. Microbiol., 97, 117-120.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.14 hydroxylysine DL-hydroxylysine Saccharomyces cerevisiae
2.3.3.14 L-Arg
-
 Saccharomyces cerevisiae
2.3.3.14 L-norleucine
-
 Saccharomyces cerevisiae
2.3.3.14 thialysine 5 mM, complete inhibition Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate Saccharomyces cerevisiae first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.14 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate
-
 Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?
2.3.3.14 acetyl-CoA + H2O + 2-oxoglutarate first enzyme of the 2-aminoadipic acid pathway for biosynthesis of lysine Saccharomyces cerevisiae 2-hydroxybutane-1,2,4-tricarboxylate + CoA
-
 ?