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Literature summary extracted from

  • Scharnagl, H.; März, W.; Schliack, M.; Löser, R.; Gross, W.
    A novel assay of cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity (1995), J. Lipid Res., 36, 622-627.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.3.10 medicine enzyme is of growing medical interest as it is highly regulated Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.3.10 cDNA cloned and sequenced Gallus gallus
2.3.3.10 cDNA cloned and sequenced Homo sapiens
2.3.3.10 cDNA cloned and sequenced Rattus norvegicus
2.3.3.10 cDNA cloned and sequenced Mesocricetus auratus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.3.10 Lifibrol
-
 Gallus gallus
2.3.3.10 Lifibrol
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.3.10 cytosol
-
 Gallus gallus 5829
-
2.3.3.10 cytosol
-
 Homo sapiens 5829
-
2.3.3.10 cytosol
-
 Rattus norvegicus 5829
-
2.3.3.10 cytosol
-
 Mesocricetus auratus 5829
-
2.3.3.10 mitochondrion
-
 Gallus gallus 5739
-
2.3.3.10 mitochondrion
-
 Homo sapiens 5739
-
2.3.3.10 mitochondrion
-
 Rattus norvegicus 5739
-
2.3.3.10 mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.3.10 53000
-
 SDS-PAGE Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Cricetulus griseus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Bos taurus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O Mesocricetus auratus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.3.10 Bos taurus
-
 ox
-
2.3.3.10 Cricetulus griseus
-
 chinese hamster
-
2.3.3.10 Gallus gallus
-
 chicken
-
2.3.3.10 Homo sapiens
-
 HepG2 cells
-
2.3.3.10 Mesocricetus auratus
-
 syrian hamster, golden hamster
-
2.3.3.10 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.3.10
-
 Bos taurus
2.3.3.10 partially Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.3.10 adrenal gland
-
 Homo sapiens
-
2.3.3.10 adrenal gland
-
 Rattus norvegicus
-
2.3.3.10 fibroblast
-
 Homo sapiens
-
2.3.3.10 liver
-
 Gallus gallus
-
2.3.3.10 liver
-
 Rattus norvegicus
-
2.3.3.10 liver
-
 Bos taurus
-
2.3.3.10 ovary
-
 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.3.10 0.0101
-
-
 Gallus gallus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Cricetulus griseus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Bos taurus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
2.3.3.10 acetyl-CoA + acetoacetyl-CoA + H2O
-
 Mesocricetus auratus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?