EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.10 | acetoacetyl-CoA | - |
Gallus gallus | |
2.3.3.10 | acetoacetyl-CoA | - |
Rattus norvegicus | |
2.3.3.10 | Mg2+ | mitochondrial enzyme | Gallus gallus | |
2.3.3.10 | palmitoyl-CoA | mitochondrial synthase | Gallus gallus | |
2.3.3.10 | succinyl-CoA | mitochondrial synthase, 50% inhibition | Gallus gallus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.10 | 0.005 | - |
acetoacetyl-CoA | - |
Gallus gallus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.3.10 | cytoplasm | - |
Rattus norvegicus | 5737 | - |
2.3.3.10 | cytoplasm | distinct mitochondrial and cytoplasmic forms | Gallus gallus | 5737 | - |
2.3.3.10 | cytosol | - |
Gallus gallus | 5829 | - |
2.3.3.10 | cytosol | - |
Rattus norvegicus | 5829 | - |
2.3.3.10 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
2.3.3.10 | mitochondrion | distinct mitochondrial and cytoplasmic forms | Gallus gallus | 5739 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.3.10 | Mg2+ | cytoplasmic enzyme | Gallus gallus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.3.10 | 53000 | - |
2 * 53000, SDS-PAGE | Gallus gallus |
2.3.3.10 | 57000 | - |
2 * 57000, gel filtration | Gallus gallus |
2.3.3.10 | 96000 | - |
gel filtration | Gallus gallus |
2.3.3.10 | 105000 | - |
sedimentation equlibrium | Gallus gallus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | mitochondrial enzyme of liver functions in ketogenesis, its cytoplasmic counterpart participates in cholesterogenesis | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.3.10 | Gallus gallus | - |
chicken | - |
2.3.3.10 | Rattus norvegicus | - |
rat | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.3.10 | mitochondrial form | Gallus gallus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.3.10 | liver | - |
Gallus gallus | - |
2.3.3.10 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.3.10 | 1 | - |
- |
Gallus gallus |
EC Number | Storage Stability | Organism |
---|---|---|
2.3.3.10 | -20°C, purified synthase may be stored for 2-3 months with little loss of activity by adding 30% glyerol | Gallus gallus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
2.3.3.10 | acetyl-CoA + acetoacetyl-CoA + H2O | mitochondrial enzyme of liver functions in ketogenesis, its cytoplasmic counterpart participates in cholesterogenesis | Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.3.10 | dimer | 2 * 53000, SDS-PAGE | Gallus gallus |
2.3.3.10 | dimer | 2 * 57000, gel filtration | Gallus gallus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.3.10 | 0.0005 | - |
palmityl-CoA | - |
Gallus gallus |