Literature summary extracted from

Ullian, M.E.; Robinson, C.J.; Evans, C.T.; Melnick, J.Z.; Fitzgibbon, W.R.
Role of citrate synthase in aldosterone-mediated sodium reabsorption (2000), Hypertension, 35, 875-879.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.3.3.1	aldosterone	-	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.3.1	mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.3.1	acetyl-CoA + oxaloacetate + H2O	Rattus norvegicus	-	citrate + CoA	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.3.1	Rattus norvegicus	-	Wistar-Furth, citrate synthase deficient strain, 28% decreased activity compared to wild-type	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.3.1	kidney	-	Rattus norvegicus	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.3.3.1	0.076	-	citrate synthase deficient strain	Rattus norvegicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.3.1	acetyl-CoA + oxaloacetate + H2O	-	Rattus norvegicus	citrate + CoA	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
2.3.3.1	8	-	enzyme assay at	Rattus norvegicus

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Release 2023.1 (January 2023)