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Literature summary extracted from

  • Bateman, R.C., Jr.; Temple, J.S.; Misquitta, S.A.; Booth, R.E.
    Evidence for essential histidines in human pituitary glutaminyl cyclase (2001), Biochemistry, 40, 11246-11250.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.3.2.5 H140Q inactive enzyme Homo sapiens
2.3.2.5 H307Q mutant enzyme with increased KM-value Homo sapiens
2.3.2.5 H319Q mutant enzyme with increased KM-value Homo sapiens
2.3.2.5 H330Q inactive enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 diethyl dicarbonate rapid inactivation by modification of three essential His residues, at neutral pH, partial reactivation with hydroxylamine Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.5 1.1
-
 Gln-NH2 wild-type enzyme Homo sapiens
2.3.2.5 4.3
-
 Gln-NH2 mutant enzyme H307Q Homo sapiens
2.3.2.5 4.9
-
 Gln-NH2 mutant enzyme H319Q Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 pituitary gland
-
 Homo sapiens
-

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.2.5 0.36
-
 Gln-NH2 mutant enzyme H319Q Homo sapiens
2.3.2.5 0.388
-
 Gln-NH2 mutant enzyme H307Q Homo sapiens
2.3.2.5 0.435
-
 Gln-NH2 unmutated enzyme Homo sapiens