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Literature summary extracted from

  • Fischer, W.H.; Spiess, J.
    Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides (1987), Proc. Natl. Acad. Sci. USA, 84, 3628-3632.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 NH4Cl 1.0 M Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.5 0.063
-
 gonadotropin releasing hormone
-
 Bos taurus
2.3.2.5 0.088
-
 [Gln1,Gly4]-thyrotropin releasing hormone
-
 Bos taurus
2.3.2.5 0.132
-
 L-Gln-L-Thr-L-Ala
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.5 secretory granule
-
 Bos taurus 30141
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.5 L-glutaminyl-peptide Rattus norvegicus
-
 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Bos taurus the enzyme may participate in the posttranslational processing of hormonal precursors to pyroglutamyl peptides 5-oxoprolyl-peptide + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Bos taurus
-
-
-
2.3.2.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.5 brain
-
 Rattus norvegicus
-
2.3.2.5 brain
-
 Bos taurus
-
2.3.2.5 hypothalamus
-
 Rattus norvegicus
-
2.3.2.5 pituitary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 gonadotropin releasing hormone
-
 Bos taurus ?
-
 ?
2.3.2.5 L-Gln-L-Thr-L-Ala
-
 Bos taurus 5-oxoprolyl-L-Thr-L-Ala + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide
-
 Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide thyrotropin-releasing hormone Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Gln-His-Pro-Glythyrotropin-releasing hormone, gonadotropin-releasing hormone and L-Gln-Tyr-Ala Rattus norvegicus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide Gln-His-Pro-Glythyrotropin-releasing hormone, gonadotropin-releasing hormone and L-Gln-Tyr-Ala Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 L-glutaminyl-peptide the enzyme may participate in the posttranslational processing of hormonal precursors to pyroglutamyl peptides Bos taurus 5-oxoprolyl-peptide + NH3
-
 ?
2.3.2.5 additional information no substrates are D-Gln-Tyr-Ala and Lys-Arg-Gln-His-Pro-Gly-Lys-Arg, i.e. thyrotropin releasing hormone precursor Rattus norvegicus ?
-
 ?
2.3.2.5 additional information no substrates are D-Gln-Tyr-Ala and Lys-Arg-Gln-His-Pro-Gly-Lys-Arg, i.e. thyrotropin releasing hormone precursor Bos taurus ?
-
 ?
2.3.2.5 [Gln1,Gly4]-thyrotropin releasing hormone
-
 Bos taurus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.5 8
-
-
 Bos taurus