Literature summary extracted from

York, M.J.; Crossley, M.J.; Hyslop, S.J.; Fisher, M.L.; Kuchel, P.W.
gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect (1989), Eur. J. Biochem., 184, 97-101.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
4.3.2.9	beta-aminoglutaryl-L-alanine	-	Homo sapiens
4.3.2.9	D-beta-aminoglutaryl-L-alanine	-	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
4.3.2.9	additional information	-	additional information	kinetics	Homo sapiens
4.3.2.9	4.48	-	5-L-Glutamyl-L-alanine	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
4.3.2.9	Homo sapiens	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
4.3.2.9	alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline	mechanism	Homo sapiens	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
4.3.2.9	erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4.3.2.9	5-L-glutamyl-L-alanine	-	Homo sapiens	5-L-oxoproline + L-alanine	-	?
4.3.2.9	5-L-glutamyl-L-amino acid	-	Homo sapiens	5-oxoproline + L-amino acid	i.e. 2-pyrrolidone-5-carboxylic acid	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
4.3.2.9	0.3	-	D-beta-aminoglutaryl-L-alanine	-	Homo sapiens

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Release 2023.1 (January 2023)