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Literature summary extracted from

  • Castonguay, R.; Lherbet, C.; Keillor, J.W.
    Mapping of the active site of rat kidney gamma-glutamyl transpeptidase using activated esters and their amide derivatives (2002), Bioorg. Med. Chem., 10, 4185-4191.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 4-aminobutyramide
-
 Rattus norvegicus
2.3.2.2 4-carboxybutyramide and derivatives Rattus norvegicus
2.3.2.2 additional information inhibition mechanism Rattus norvegicus
2.3.2.2 N-acetyl-L-glutamine poor inhibitor, competitive Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.2
-
 Rattus norvegicus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.2 a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site Rattus norvegicus
a
2.3.2.2 a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid almost the entire glutamyl moiety is necessary for recognition in the binding site of the donor substrate Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 additional information ester and amide derivatives of L-Glu-4-nitroanilide are no substrates, overview Rattus norvegicus ?
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.2 additional information
-
 additional information Ki-values for derivatives of 4-acrboxybutyramide, overview Rattus norvegicus
2.3.2.2 12.6
-
 4-carboxybutyramide
-
 Rattus norvegicus
2.3.2.2 23.2
-
 4-aminobutyramide
-
 Rattus norvegicus