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Literature summary extracted from

  • Ingbar, D.H.; Hepler, K.; Dowin, R.; Jacobsen, E.; Dunitz, J.M.; Nici, L.; Jamieson, J.D.
    gamma-Glutamyl transpeptidase is a polarized alveolar epithelial membrane protein (1995), Am. J. Physiol., 269, L261-L271.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.2 extracellular extrinsic to plasma membrane Rattus norvegicus
-
-
2.3.2.2 membrane polarized, outer apical surface alveolar epithelium Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Rattus norvegicus
-
 peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 glutathione + an amino acid Rattus norvegicus ectoenzyme protects the epithelial cells against oxidants by replenishing intracellular glutathione L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Rattus norvegicus
-
 male, Sprague-Dawley
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.2 glycoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 cell culture
-
 Rattus norvegicus
-
2.3.2.2 epithelium alveolar and bronchial, type I and type II cells Rattus norvegicus
-
2.3.2.2 lung alveolar and ciliated bronchial epithelium Rattus norvegicus
-
2.3.2.2 lung fibroblast
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.2.2 additional information
-
 activity during developmental stages in lung epithelial cells type I and II Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+
-
 Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 glutathione + an amino acid ectoenzyme protects the epithelial cells against oxidants by replenishing intracellular glutathione Rattus norvegicus L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?