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Literature summary extracted from

  • Minato, S.
    Isolation of anthglutin, an inhibitor of gamma-glutamyl transpeptidase from Penicillum oxalicum (1979), Arch. Biochem. Biophys., 192, 235-240.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine
-
 Canis lupus familiaris
2.3.2.2 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine methionine protects in vivo; transpeptidation, competitive to the glutamyl-donor, kinetics Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Canis lupus familiaris
-
-
-
2.3.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 bile
-
 Homo sapiens
-
2.3.2.2 blood serum Homo sapiens
-
2.3.2.2 ileum
-
 Homo sapiens
-
2.3.2.2 intestine
-
 Homo sapiens
-
2.3.2.2 kidney
-
 Homo sapiens
-
2.3.2.2 kidney
-
 Canis lupus familiaris
-
2.3.2.2 liver
-
 Homo sapiens
-
2.3.2.2 rectum
-
 Homo sapiens
-
2.3.2.2 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+
-
 Canis lupus familiaris peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ concurrent reaction: hydrolase reaction with H2O as acceptor Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ concurrent reaction: autotranspeptidation with another donor molecule as acceptor Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine
-
 Homo sapiens 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine
-
 Canis lupus familiaris 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.2 37
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.2 additional information
-
 additional information 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine: Ki values in different tissues, overview Homo sapiens
2.3.2.2 0.0057
-
 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine
-
 Canis lupus familiaris
2.3.2.2 0.0102
-
 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine membrane-bound liver enzyme Homo sapiens
2.3.2.2 0.0136
-
 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine soluble liver enzyme Homo sapiens
2.3.2.2 0.0183
-
 5-L-glutamyl-2-(2-carboxyphenyl)hydrazine kidney enzyme Homo sapiens