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Literature summary extracted from

  • Shaw, L.M.; Stromme, J.H.
    gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 3. IFCC reference method (provisional) (1983), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 3, 357-364.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 5-(L-alpha-glutamylamino)-2-nitrobenzoic acid weak Homo sapiens
2.3.2.2 5-(L-gamma-glutamylamino)-2-nitrobenzoic acid enzyme from human tissues, not serum Homo sapiens
2.3.2.2 additional information
-
 Homo sapiens
2.3.2.2 Tris(hydroxymethyl)aminomethane
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.2 0.65
-
 5-L-glutamyl 3-carboxy-4-nitroanilide
-
 Homo sapiens
2.3.2.2 3.61
-
 D-Glu-3-carboxy-4-nitroanilide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.2 extracellular
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 blood serum Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.2.2 additional information
-
 assay method Homo sapiens

Storage Stability

EC Number Storage Stability Organism
2.3.2.2 -80°C, 9 months Homo sapiens
2.3.2.2 4°C, at least 5 days Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor binding site reacts with L- and to a lesser extent D-enantiomer Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ir
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ strict L-stereospecificity of 5-Glu-acceptor site Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ir
2.3.2.2 5-D-glutamyl 3-carboxy-4-nitroanilide + glycylglycine
-
 Homo sapiens 5-D-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl 3-carboxy-4-nitroanilide + glucana
-
 Homo sapiens 5-amino-2-nitrobenzoic acid + N-(3-carboxy-4-nitrophenyl)-L-glutaminyl-L-glutamic acid
-
 ir
2.3.2.2 5-L-glutamyl 3-carboxy-4-nitroanilide + glycylglycine
-
 Homo sapiens 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl 3-carboxy-4-nitronailide + glycylglycine
-
 Homo sapiens 5-amino-2-nitrobenzoic acid + 5-L-glutamylglycylglycine
-
 ir
2.3.2.2 5-L-glutamyl-3-carboxy-4-nitroanilide + 5-L-glutamyl-3-carboxy-4-nitroanilide
-
 Homo sapiens 5-L-glutamyl-5-L-glutamyl-3-carboxy-4-nitroanilide + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Homo sapiens 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine
-
 Homo sapiens 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ir

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.2 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.2 7.9
-
-
 Homo sapiens