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Literature summary extracted from

  • Shaw, L.M.
    gamma-Glutamyltransferase. (gamma-Glutamyl)-peptide:amino acid gamma-glutamyltransferase, EC 2.3.2.2. 1. General (1983), Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. ), 3, 349-352.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.2 5-(L-gamma-glutamylamino)-2-nitrobenzoic acid enzyme from human tissues, not serum Homo sapiens
2.3.2.2 glycine
-
 Homo sapiens
2.3.2.2 glycine
-
 Rattus norvegicus
2.3.2.2 glycylglycine
-
 Homo sapiens
2.3.2.2 glycylglycine
-
 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.2 extracellular
-
 Homo sapiens
-
-
2.3.2.2 extracellular
-
 Rattus norvegicus
-
-
2.3.2.2 membrane extrinsic to plasma membrane Homo sapiens 16020
-
2.3.2.2 membrane extrinsic to plasma membrane Rattus norvegicus 16020
-
2.3.2.2 membrane extrinsic to plasma membrane Oryctolagus cuniculus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.2 86000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.2 glutathione + an amino acid Homo sapiens involved in 5-L-glutamyl cycle of glutathione metabolism L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?
2.3.2.2 glutathione + an amino acid Oryctolagus cuniculus involved in 5-L-glutamyl cycle of glutathione metabolism L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.2 Homo sapiens
-
-
-
2.3.2.2 Oryctolagus cuniculus
-
-
-
2.3.2.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.2 glycoprotein rich in carbohydrates Homo sapiens
2.3.2.2 glycoprotein rich in carbohydrates Rattus norvegicus
2.3.2.2 glycoprotein rich in carbohydrates Oryctolagus cuniculus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.2 a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site on small subunit Homo sapiens
a
2.3.2.2 a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid active site on small subunit Rattus norvegicus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.2 blood serum Homo sapiens
-
2.3.2.2 duodenum
-
 Homo sapiens
-
2.3.2.2 duodenum
-
 Rattus norvegicus
-
2.3.2.2 duodenum
-
 Oryctolagus cuniculus
-
2.3.2.2 epithelium proximal tubular Rattus norvegicus
-
2.3.2.2 intestine
-
 Homo sapiens
-
2.3.2.2 intestine
-
 Rattus norvegicus
-
2.3.2.2 intestine
-
 Oryctolagus cuniculus
-
2.3.2.2 kidney luminal membrane of proximal tubules Homo sapiens
-
2.3.2.2 kidney luminal membrane of proximal tubules Rattus norvegicus
-
2.3.2.2 liver
-
 Homo sapiens
-
2.3.2.2 liver
-
 Rattus norvegicus
-
2.3.2.2 liver
-
 Oryctolagus cuniculus
-
2.3.2.2 lymphoid cell
-
 Homo sapiens
-
2.3.2.2 pancreas
-
 Rattus norvegicus
-
2.3.2.2 pancreas
-
 Oryctolagus cuniculus
-
2.3.2.2 pancreas acinar cells, apical part Homo sapiens
-
2.3.2.2 prostate gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-3-sulfonic-4-nitroanilide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: GSH S-substituted derivatives Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is 5-L-Glu-4-nitroanilide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptors are amino acids or dipeptides Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ donor: 5-L-Glu-naphthylamide Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Homo sapiens peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 (5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Oryctolagus cuniculus peptide + 5-L-glutamyl amino acid
-
 ?
2.3.2.2 5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Homo sapiens 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Rattus norvegicus 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
-
 Oryctolagus cuniculus 5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Homo sapiens 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + glycylglycine best acceptor Oryctolagus cuniculus 4-nitroaniline + 5-L-glutamylglycylglycine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + L-cystine
-
 Homo sapiens 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + L-cystine
-
 Rattus norvegicus 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
2.3.2.2 5-L-glutamyl-4-nitroanilide + L-cystine
-
 Oryctolagus cuniculus 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
2.3.2.2 glutathione + acceptor
-
 Homo sapiens cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
2.3.2.2 glutathione + acceptor
-
 Rattus norvegicus cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
2.3.2.2 glutathione + acceptor
-
 Oryctolagus cuniculus cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
2.3.2.2 glutathione + an amino acid involved in 5-L-glutamyl cycle of glutathione metabolism Homo sapiens L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?
2.3.2.2 glutathione + an amino acid involved in 5-L-glutamyl cycle of glutathione metabolism Oryctolagus cuniculus L-cysteinylglycine + a 5-L-glutamyl-amino acid
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.2.2 More the active site resides on the small subunit Homo sapiens
2.3.2.2 More the active site resides on the small subunit Rattus norvegicus