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Literature summary extracted from

  • Folk, J.E.; Chung, S.I.
    Molecular and catalytic properties of transglutaminases (1973), Adv. Enzymol. Relat. Areas Mol. Biol., 38, 109-191.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 papain limited proteolysis of plasma factor XIII Homo sapiens
2.3.2.13 reptilase limited proteolysis of plasma factor XIII Homo sapiens
2.3.2.13 thrombin
-
Homo sapiens
2.3.2.13 thrombin activation, of proenzyme Cavia porcellus
2.3.2.13 Trypsin
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 5,5'-dithiobis(2-nitrobenzoic acid) reversed by dithiothreitol Cavia porcellus
2.3.2.13 Cu2+ KCN or dithiothreitol restore activity; mechanism Cavia porcellus
2.3.2.13 Cu2+
-
Homo sapiens
2.3.2.13 EDTA
-
Cavia porcellus
2.3.2.13 EDTA
-
Homo sapiens
2.3.2.13 Fe2+
-
Cavia porcellus
2.3.2.13 Hg2+
-
Cavia porcellus
2.3.2.13 iodoacetamide 0.1 mM, pH 6.8, in the presence of Ca2+, complete inhibition, irreversible, incorporation of 1 mol carbamidomethyl/mol enzyme, substrate protects; mechanism Cavia porcellus
2.3.2.13 iodoacetamide
-
Homo sapiens
2.3.2.13 tetrathionate inactivation, not reversible by dithiothreitol Cavia porcellus
2.3.2.13 Zn2+
-
Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.13 additional information
-
additional information
-
Homo sapiens
2.3.2.13 additional information
-
additional information kinetic mechanism Cavia porcellus
2.3.2.13 7
-
benzyloxycarbonyl-L-glutaminylglycine
-
Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 soluble
-
Cavia porcellus
-
-
2.3.2.13 soluble
-
Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ba2+ activation, can replace Ca2+ to a lesser extent Cavia porcellus
2.3.2.13 Ca2+ requirement Cavia porcellus
2.3.2.13 Ca2+ requirement Homo sapiens
2.3.2.13 Ca2+ 1 mM Cavia porcellus
2.3.2.13 Ca2+ 1 mM Homo sapiens
2.3.2.13 Ca2+ mechanism Cavia porcellus
2.3.2.13 Mg2+ slight activation Cavia porcellus
2.3.2.13 Mg2+ slight activation Homo sapiens
2.3.2.13 Mn2+
-
Cavia porcellus
2.3.2.13 Mn2+
-
Homo sapiens
2.3.2.13 Sr2+
-
Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 27000
-
2 * 27000, hair follicle transglutaminase, SDS-PAGE Cavia porcellus
2.3.2.13 54000
-
hair follicle transglutaminase, gel filtration Cavia porcellus
2.3.2.13 55000
-
-
Homo sapiens
2.3.2.13 55000
-
hair follicle transglutaminase, native PAGE Cavia porcellus
2.3.2.13 76900
-
sedimentation and diffusion Cavia porcellus
2.3.2.13 85000
-
1 * 85000, SDS-PAGE Cavia porcellus
2.3.2.13 86000 94000 sedimentation equilibrium Cavia porcellus
2.3.2.13 280000 330000 plasma factor XIII, gel filtration and sedimentation equilibrium Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-
2.3.2.13 Homo sapiens
-
zymogen factor XIII i.e. proenzyme of XIIIa
-
2.3.2.13 Homo sapiens
-
coagulation factor XIIIa
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.13 additional information no glycoprotein Cavia porcellus
2.3.2.13 additional information no glycoprotein Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.13
-
Cavia porcellus
2.3.2.13
-
Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Cavia porcellus
2.3.2.13 protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 structure, function, evolution Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 blood plasma
-
Homo sapiens
-
2.3.2.13 blood platelet
-
Homo sapiens
-
2.3.2.13 hair follicle not related to liver enzyme Cavia porcellus
-
2.3.2.13 liver
-
Cavia porcellus
-
2.3.2.13 liver
-
Homo sapiens
-
2.3.2.13 placenta
-
Homo sapiens
-
2.3.2.13 uterus
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 benzyloxycarbonyl-L-glutaminglycine + glycine ethyl ester
-
Cavia porcellus benzyloxycarbonyl-alpha-L-glutamyl(gamma-glycine ethyl ester)glycine + NH3
-
r
2.3.2.13 p-nitrophenyl acetate + alanine ethylester
-
Cavia porcellus N-acetylalanine ethylester + p-nitrophenol
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine acyl-transfer reaction Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine acyl-transfer reaction Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine liver transglutaminase, amine donors: putrescine, phenylethylamine, glycinamide, histamine, methylamine, ethanolamine, amonia Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine no activity with benzyloxycarbonyl-L-glutaminylglycine, benzyloxycarbonyl-alpha-L-glutamyl(gamma-p-nitrophenyl ester) glycine, guinea pig hair follicle enzyme Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine broad specificity towards amine acceptor Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine broad specificity towards amine acceptor Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine no amine donors are tyrosinamide, glycine, Gly-Leu, gamma-aminobutyric acid Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine no amine donors are tyrosinamide, glycine, Gly-Leu, gamma-aminobutyric acid Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrates are fibrinogen, beta-lactoglobulin, casein, insulin Cavia porcellus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine substrates are fibrinogen, beta-lactoglobulin, casein, insulin Homo sapiens protein N5-alkylglutamine + NH3
-
?

Subunits

EC Number Subunits Comment Organism
2.3.2.13 dimer 2 * 27000, hair follicle transglutaminase, SDS-PAGE Cavia porcellus
2.3.2.13 monomer
-
Homo sapiens
2.3.2.13 monomer 1 * 85000, SDS-PAGE Cavia porcellus
2.3.2.13 monomer 1 * 80000-90000, gel filtration in 6 M guanidine Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.13 additional information
-
-
Homo sapiens
2.3.2.13 additional information
-
optima depend on amine donor substrate Cavia porcellus
2.3.2.13 6
-
approx. value, hydrolysis reaction Cavia porcellus
2.3.2.13 6
-
approx. value, hydrolysis reaction Homo sapiens