EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.13 | papain | limited proteolysis of plasma factor XIII | Homo sapiens | |
2.3.2.13 | reptilase | limited proteolysis of plasma factor XIII | Homo sapiens | |
2.3.2.13 | thrombin | - |
Homo sapiens | |
2.3.2.13 | thrombin | activation, of proenzyme | Cavia porcellus | |
2.3.2.13 | Trypsin | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.13 | 5,5'-dithiobis(2-nitrobenzoic acid) | reversed by dithiothreitol | Cavia porcellus | |
2.3.2.13 | Cu2+ | KCN or dithiothreitol restore activity; mechanism | Cavia porcellus | |
2.3.2.13 | Cu2+ | - |
Homo sapiens | |
2.3.2.13 | EDTA | - |
Cavia porcellus | |
2.3.2.13 | EDTA | - |
Homo sapiens | |
2.3.2.13 | Fe2+ | - |
Cavia porcellus | |
2.3.2.13 | Hg2+ | - |
Cavia porcellus | |
2.3.2.13 | iodoacetamide | 0.1 mM, pH 6.8, in the presence of Ca2+, complete inhibition, irreversible, incorporation of 1 mol carbamidomethyl/mol enzyme, substrate protects; mechanism | Cavia porcellus | |
2.3.2.13 | iodoacetamide | - |
Homo sapiens | |
2.3.2.13 | tetrathionate | inactivation, not reversible by dithiothreitol | Cavia porcellus | |
2.3.2.13 | Zn2+ | - |
Cavia porcellus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.2.13 | additional information | - |
additional information | - |
Homo sapiens | |
2.3.2.13 | additional information | - |
additional information | kinetic mechanism | Cavia porcellus | |
2.3.2.13 | 7 | - |
benzyloxycarbonyl-L-glutaminylglycine | - |
Cavia porcellus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.2.13 | soluble | - |
Cavia porcellus | - |
- |
2.3.2.13 | soluble | - |
Homo sapiens | - |
- |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.2.13 | Ba2+ | activation, can replace Ca2+ to a lesser extent | Cavia porcellus | |
2.3.2.13 | Ca2+ | requirement | Cavia porcellus | |
2.3.2.13 | Ca2+ | requirement | Homo sapiens | |
2.3.2.13 | Ca2+ | 1 mM | Cavia porcellus | |
2.3.2.13 | Ca2+ | 1 mM | Homo sapiens | |
2.3.2.13 | Ca2+ | mechanism | Cavia porcellus | |
2.3.2.13 | Mg2+ | slight activation | Cavia porcellus | |
2.3.2.13 | Mg2+ | slight activation | Homo sapiens | |
2.3.2.13 | Mn2+ | - |
Cavia porcellus | |
2.3.2.13 | Mn2+ | - |
Homo sapiens | |
2.3.2.13 | Sr2+ | - |
Cavia porcellus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.2.13 | 27000 | - |
2 * 27000, hair follicle transglutaminase, SDS-PAGE | Cavia porcellus |
2.3.2.13 | 54000 | - |
hair follicle transglutaminase, gel filtration | Cavia porcellus |
2.3.2.13 | 55000 | - |
- |
Homo sapiens |
2.3.2.13 | 55000 | - |
hair follicle transglutaminase, native PAGE | Cavia porcellus |
2.3.2.13 | 76900 | - |
sedimentation and diffusion | Cavia porcellus |
2.3.2.13 | 85000 | - |
1 * 85000, SDS-PAGE | Cavia porcellus |
2.3.2.13 | 86000 | 94000 | sedimentation equilibrium | Cavia porcellus |
2.3.2.13 | 280000 | 330000 | plasma factor XIII, gel filtration and sedimentation equilibrium | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.2.13 | Cavia porcellus | - |
- |
- |
2.3.2.13 | Homo sapiens | - |
zymogen factor XIII i.e. proenzyme of XIIIa | - |
2.3.2.13 | Homo sapiens | - |
coagulation factor XIIIa | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.3.2.13 | additional information | no glycoprotein | Cavia porcellus |
2.3.2.13 | additional information | no glycoprotein | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.2.13 | - |
Cavia porcellus |
2.3.2.13 | - |
Homo sapiens |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.2.13 | protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Cavia porcellus | |
2.3.2.13 | protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.2.13 | blood plasma | - |
Homo sapiens | - |
2.3.2.13 | blood platelet | - |
Homo sapiens | - |
2.3.2.13 | hair follicle | not related to liver enzyme | Cavia porcellus | - |
2.3.2.13 | liver | - |
Cavia porcellus | - |
2.3.2.13 | liver | - |
Homo sapiens | - |
2.3.2.13 | placenta | - |
Homo sapiens | - |
2.3.2.13 | uterus | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.2.13 | benzyloxycarbonyl-L-glutaminglycine + glycine ethyl ester | - |
Cavia porcellus | benzyloxycarbonyl-alpha-L-glutamyl(gamma-glycine ethyl ester)glycine + NH3 | - |
r | |
2.3.2.13 | p-nitrophenyl acetate + alanine ethylester | - |
Cavia porcellus | N-acetylalanine ethylester + p-nitrophenol | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | acyl-transfer reaction | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | acyl-transfer reaction | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | liver transglutaminase, amine donors: putrescine, phenylethylamine, glycinamide, histamine, methylamine, ethanolamine, amonia | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | no activity with benzyloxycarbonyl-L-glutaminylglycine, benzyloxycarbonyl-alpha-L-glutamyl(gamma-p-nitrophenyl ester) glycine, guinea pig hair follicle enzyme | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | broad specificity towards amine acceptor | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | broad specificity towards amine acceptor | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | no amine donors are tyrosinamide, glycine, Gly-Leu, gamma-aminobutyric acid | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | no amine donors are tyrosinamide, glycine, Gly-Leu, gamma-aminobutyric acid | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | substrates are fibrinogen, beta-lactoglobulin, casein, insulin | Cavia porcellus | protein N5-alkylglutamine + NH3 | - |
? | |
2.3.2.13 | protein-bound gamma-glutamine + alkylamine | substrates are fibrinogen, beta-lactoglobulin, casein, insulin | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.2.13 | dimer | 2 * 27000, hair follicle transglutaminase, SDS-PAGE | Cavia porcellus |
2.3.2.13 | monomer | - |
Homo sapiens |
2.3.2.13 | monomer | 1 * 85000, SDS-PAGE | Cavia porcellus |
2.3.2.13 | monomer | 1 * 80000-90000, gel filtration in 6 M guanidine | Cavia porcellus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.2.13 | additional information | - |
- |
Homo sapiens |
2.3.2.13 | additional information | - |
optima depend on amine donor substrate | Cavia porcellus |
2.3.2.13 | 6 | - |
approx. value, hydrolysis reaction | Cavia porcellus |
2.3.2.13 | 6 | - |
approx. value, hydrolysis reaction | Homo sapiens |