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Literature summary extracted from

  • Chang, S.K.; Chung, S.I.
    Cellular transglutaminase. The particulate-associated transglutaminase from chondrosarcoma and liver: partial purification and characterization (1986), J. Biol. Chem., 261, 8112-8121.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 thrombin
-
 Cavia porcellus
2.3.2.13 thrombin
-
 Homo sapiens
2.3.2.13 thrombin guinea pig epidermal enzyme Rattus norvegicus
2.3.2.13 thrombin particulate enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 iodoacetamide
-
 Cavia porcellus
2.3.2.13 iodoacetamide
-
 Homo sapiens
2.3.2.13 iodoacetamide 86% and 91% inhibition of chondrosarcoma transglutaminase B and C respectively Rattus norvegicus
2.3.2.13 additional information
-
 Cavia porcellus
2.3.2.13 additional information
-
 Homo sapiens
2.3.2.13 additional information not inhibited by diisopropylfluorophosphate; not inhibited by PMSF; not inhibited by sulfhydryl-reagents in the absence of Ca2+ Rattus norvegicus
2.3.2.13 N-iodoacetyl-N'-(5-sulfo-1-naphthyl)ethylenediamine 0.01 mM, 91% and 92% inhibition of chondrosarcoma transglutaminases B and C respectively Rattus norvegicus
2.3.2.13 p-chloromercuribenzoate
-
 Cavia porcellus
2.3.2.13 p-chloromercuribenzoate 21% inhibition of chondrosarcoma transglutaminase B Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.13 additional information
-
 additional information
-
 Cavia porcellus
2.3.2.13 additional information
-
 additional information
-
 Homo sapiens
2.3.2.13 additional information
-
 additional information kinetic study with various transglutaminases: human factor XIIIa, guinea pig liver TGC, rat chondrosarcoma TGB Rattus norvegicus
2.3.2.13 0.024
-
 methylamine transglutaminase C Cavia porcellus
2.3.2.13 0.051
-
 methylamine chondrosarcoma transglutaminase B Rattus norvegicus
2.3.2.13 0.061
-
 methylamine factor XIIIa Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.13 particle-bound
-
 Cavia porcellus
-
-
2.3.2.13 particle-bound
-
 Homo sapiens
-
-
2.3.2.13 particle-bound
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Cavia porcellus
2.3.2.13 Ca2+ requirement Homo sapiens
2.3.2.13 Ca2+ requirement Rattus norvegicus
2.3.2.13 Mn2+
-
 Cavia porcellus
2.3.2.13 Mn2+
-
 Homo sapiens
2.3.2.13 Mn2+ slight activation Rattus norvegicus
2.3.2.13 additional information
-
 Homo sapiens
2.3.2.13 additional information not activated by Cu2+ Rattus norvegicus
2.3.2.13 Sr2+
-
 Cavia porcellus
2.3.2.13 Sr2+ slight activation Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.2.13 80000
-
-
 Homo sapiens
2.3.2.13 80000
-
 liver and chondrosarcoma transglutaminase C, gel filtration Rattus norvegicus
2.3.2.13 100000
-
 liver and chondrosarcoma transglutaminase B Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Cavia porcellus
-
-
-
2.3.2.13 Homo sapiens
-
-
-
2.3.2.13 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.2.13 glycoprotein chondrosarcoma transglutaminase Rattus norvegicus

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.13 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 chondrocyte malignant, swarm chondrosarcoma Rattus norvegicus
-
2.3.2.13 liver
-
 Cavia porcellus
-
2.3.2.13 liver
-
 Homo sapiens
-
2.3.2.13 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 methylamine + succinyl-beta-casein transglutaminase B Rattus norvegicus ?
-
 ?
2.3.2.13 methylamine + succinylated alpha-casein
-
 Cavia porcellus ?
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine
-
 Cavia porcellus protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine
-
 Homo sapiens protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine chondrosarcoma transglutaminase B, no activity with type I collagen and fibronectin Rattus norvegicus protein N5-alkylglutamine + NH3
-
 ?
2.3.2.13 protein-bound gamma-glutamine + alkylamine transglutaminase B: simultaneously gamma-polymer and alpha-polymer formation Rattus norvegicus protein N5-alkylglutamine + NH3
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.2.13 0.32
-
 methylamine chondrosarcoma transglutaminase B Rattus norvegicus
2.3.2.13 0.467
-
 methylamine transglutaminase C Cavia porcellus
2.3.2.13 1.86
-
 methylamine factor XIIIa Homo sapiens