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Literature summary extracted from

  • Puzkin, E.G.; Raghuraman, V.
    Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard (1985), J. Biol. Chem., 260, 16012-16020.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.2.13 Calmodulin/Ca2+ 0.01-0.2 mM, 3fold activation, inhibition above 0.3 mM, kinetics Gallus gallus
2.3.2.13 Calmodulin/Ca2+ 0.01-0.2 mM, 3fold activation, inhibition above 0.3 mM, kinetics Homo sapiens
2.3.2.13 thrombin slight activation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.13 chlorpromazine reverses calmodulin enzyme stimulation Gallus gallus
2.3.2.13 chlorpromazine reverses calmodulin enzyme stimulation Homo sapiens
2.3.2.13 iodoacetamide factor XIIIa; not inhibited in the absence of Ca2+, calmodulin regulated transglutaminases is not inhibited Gallus gallus
2.3.2.13 iodoacetamide factor XIIIa; not inhibited in the absence of Ca2+, calmodulin regulated transglutaminases is not inhibited Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.13 0.006
-
casein plasma factor XII, actin Gallus gallus
2.3.2.13 0.007
-
actin platelet transglutaminase Homo sapiens
2.3.2.13 0.011
-
casein platelet transglutaminase Homo sapiens
2.3.2.13 0.012
-
casein gizzard transglutaminase Gallus gallus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.13 Ca2+ requirement Gallus gallus
2.3.2.13 Ca2+ requirement Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.13 protein-bound gamma-glutamine + alkylamine Gallus gallus last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine Homo sapiens last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.13 Gallus gallus
-
-
-
2.3.2.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.2.13 co-purified with alpha-actinin Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.13 blood platelet
-
Homo sapiens
-
2.3.2.13 gizzard smooth muscle Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.13 monodansyl- cadaverine + actin
-
Homo sapiens ?
-
?
2.3.2.13 N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + casein
-
Gallus gallus ?
-
?
2.3.2.13 N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + casein
-
Homo sapiens ?
-
?
2.3.2.13 N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + F-actin trivial name dansylcadaverine Gallus gallus ?
-
?
2.3.2.13 N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide + F-actin trivial name dansylcadaverine Homo sapiens ?
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Gallus gallus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine donors: gamma-carboxamide groups of protein-bound glutamine, acceptors: epsilon-amino groups of protein-bound lysine Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Gallus gallus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Gallus gallus protein N5-alkylglutamine + NH3
-
?
2.3.2.13 protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?