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Literature summary extracted from

  • Thompson, J.; Kim, D.F.; O'Connor, M.; Lieberman, K.R.; Bayfield, M.A.; Gregory, S.T.; Green, R.; Noller, H.F.; Dahlberg, A.E.
    Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit (2001), Proc. Natl. Acad. Sci. USA, 98, 9002-9007.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 chloramphenicol weak peptide bond formation inhibition only by ribosomes with A2451C, A2451U or A2451G, peptide bond formation inhibition by ribosomes with G2447A is essentially unimpaired Geobacillus stearothermophilus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.12 ribosome 50S subunit, wild type ribosomes, ribosomes with site-directed mutated residues: A2451, G2447 Geobacillus stearothermophilus 5840
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Geobacillus stearothermophilus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 N-AcMet-tRNA + puromycin
-
 Geobacillus stearothermophilus tRNA + N-AcMet-puromycin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.12 45
-
 enzyme assay Geobacillus stearothermophilus