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Literature summary extracted from

  • Cerna, J.; Rychlik, I.; Lichtenthaler, F.W.
    The effect of the aminoacyl-4-aminohexosyl-cytosine group of antibiotics on ribosomal peptidyl transferase (1973), FEBS Lett., 30, 147-150.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.12 Amicetin complete inhibition with AcPhe-tRNA as donor, with polylysyl-tRNA as donor less active Escherichia coli
2.3.2.12 Bamicetin complete inhibition with AcPhe-tRNA as donor, with polylysyl-tRNA as donor less active Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.2.12 ribosome
-
 Escherichia coli 5840
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.12 peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 Escherichia coli
-
 tRNA1 + peptidyl-amino-tRNA2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.12 Escherichia coli
-
 B cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.12 AcPhe-tRNA + puromycin reaction only in the presence of 70S ribosomes and the appropriate mRNA Escherichia coli tRNA + AcPhe-puromycin
-
 ?
2.3.2.12 CACCA-AcLeu + puromycin fragment reaction Escherichia coli CACCA + AcLeu-puromycin
-
 ?
2.3.2.12 peptidyl-tRNA1 + alpha-aminoacyl-tRNA2
-
 Escherichia coli tRNA1 + peptidyl-amino-tRNA2
-
 ?
2.3.2.12 polylysyl-tRNA + puromycin reaction only in the presence of 70S ribosomes and the appropriate mRNA Escherichia coli tRNA + polylysyl-puromycin
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.2.12 35
-
 enzyme assay Escherichia coli