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Literature summary extracted from
- Inhibitory effect of spermine on ribosomal peptidyltransferase (1993), Arch. Biochem. Biophys., 300, 629-634.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.3.2.12 | spermine | competitive inhibitor of peptide bond formation at the kinetic phase of the puromycin reaction | Escherichia coli |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.3.2.12 | ribosome | additionally factors washable from ribosomes | Escherichia coli | 5840 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.3.2.12 | peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | Escherichia coli | - |
tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.3.2.12 | Escherichia coli | - |
B cells | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.3.2.12 | AcPhe-tRNA + puromycin | - |
Escherichia coli | tRNA + AcPhe-puromycin | - |
? | |
| 2.3.2.12 | peptidyl-tRNA1 + alpha-aminoacyl-tRNA2 | - |
Escherichia coli | tRNA1 + peptidyl-amino-tRNA2 | - |
? | |
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Release 2023.1 (January 2023)
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