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Literature summary extracted from

  • Sogabe, S.; Masubuchi, M.; Sakata, K.; Fukami, T.A.; Morikami, K.; Shiratori, Y.; Ebiike, H.; Kawasaki, K.; Aoki, Y.; Shimma, N.; D'Arcy, A.; Winkler, F.K.; Banner, D.W.; Ohtsuka, T.
    Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors (2002), Chem. Biol., 9, 1119-1128.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.97 medicine target for antiviral and antifungal therapy Candida albicans

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.97 ternary complex formation incubation of protein, 60 mg/ml, with 5fold molar of myristoyl-CoA and inhibitor SC-58272 for a few hours, hanging drop at 4°C, from 0.2 M ammonium acetate, 50 mM HEPES, pH 7.5, 10-12% polyethylene glycol 3350, 2-3 weeks, crystal structure determination by X-ray diffraction analysis Candida albicans

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.97 additional information diverse mutants, evaluation of inhibition mechanism of inhibitor SC-58272 and compounds 1-5 Candida albicans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 benzyl-{3-[2-(2-ethoxymethyl-benzofuran-5-ylmethoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-amine
-
 Candida albicans
2.3.1.97 ethyl 4-[2-hydroxy-3-(isopropylamino)propoxy]-3-methyl-1-benzofuran-2-carboxylate
-
 Candida albicans
2.3.1.97 additional information inhibition mechanism; inhibitor binding site Candida albicans
2.3.1.97 SC-58272
-
 Candida albicans
2.3.1.97 {3-[2-(1H-imidazol-2-yl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine
-
 Candida albicans
2.3.1.97 {3-[2-(2,3-difluoro-phenoxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine
-
 Candida albicans
2.3.1.97 {3-[2-(2-ethoxymethyl-benzofuran-5-yloxymethyl)-3-methyl-benzofuran-4-yloxy]-propyl}-pyridin-3-ylmethyl-amine
-
 Candida albicans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.97 45000
-
 1 * 45000, SDS-PAGE Candida albicans
2.3.1.97 46000
-
 mass spectroscopy Candida albicans

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Candida albicans
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + glycylpeptide
-
 Candida albicans N-myristoylglycylpeptide + CoA
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.97 monomer 1 * 45000, SDS-PAGE Candida albicans

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 NMT
-
 Candida albicans

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.97 additional information
-
 additional information
-
 Candida albicans