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Literature summary extracted from

  • King, M.J.; Sharma, R.K.
    Differential activation of bovine brain N-myristoyltransferase(s) by a cytosolic activator (1995), Biochem. Biophys. Res. Commun., 212, 580-588.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.97 N-myristoyltransferase activator NAF45 increase of Km for peptide substrates Bos taurus
2.3.1.97 N-myristoyltransferase activator NAF45 absolutely required for activity of brain enzyme isoforms, maximal 3-4fold activation Bos taurus
2.3.1.97 N-myristoyltransferase activator NAF45 from brain, 45 kDa protein Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 factor NIP71 competitive against activation factor NAF45 Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.97 additional information
-
additional information
-
Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Bos taurus
-
at least 4 isoforms in the brain
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.97 isoform from brain bound to NAF45 Bos taurus

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.3.1.97 reconstitution of activity by rebuilding enzyme-NAF45 complex Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.97 brain
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + cAMP-dependent protein kinase-derived peptide
-
Bos taurus N-myristoylated cAMP-dependent protein kinase-derived peptide + CoA
-
?
2.3.1.97 myristoyl-CoA + glycylpeptide specific for Gly at N-terminus Bos taurus N-myristoylglycylpeptide + CoA
-
?
2.3.1.97 myristoyl-CoA + p60src-derived peptide
-
Bos taurus N-myristoylated p60src-derived peptide + CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 NMT
-
Bos taurus