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Literature summary extracted from

  • Wagner, A.P.; Retey, J.
    Synthesis of myristoyl-carba(dethia)-coenzyme A and S-(3-oxohexadecyl)-coenzyme A, two potent inhibitors of myristoyl-CoA: protein N-myristoyltransferase (1991), Eur. J. Biochem., 195, 699-705.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.97 myristoyl-carba(dethia)-CoA
-
 Saccharomyces cerevisiae
2.3.1.97 S-(2-Oxo)-pentadecyl-CoA
-
 Saccharomyces cerevisiae
2.3.1.97 S-(3-Oxohexadecyl)-CoA
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.97 myristoyl-CoA + vinculin Saccharomyces cerevisiae
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.97 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.97 partial Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.97 myristoyl-CoA + glycylpeptide
-
 Saccharomyces cerevisiae N-myristoylglycylpeptide + CoA
-
 ?
2.3.1.97 myristoyl-CoA + vinculin
-
 Saccharomyces cerevisiae ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.97 NMT
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.97 30
-
 assay at Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.97 7.4
-
 assay at Saccharomyces cerevisiae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.97 0.000024
-
 S-(2-Oxo)-pentadecyl-CoA
-
 Saccharomyces cerevisiae
2.3.1.97 0.00025
-
 S-(3-Oxohexadecyl)-CoA
-
 Saccharomyces cerevisiae
2.3.1.97 0.0003
-
 myristoyl-carba(dethia)-CoA
-
 Saccharomyces cerevisiae