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Literature summary extracted from

  • Greenspan, M.D.; Yudkovitz, J.B.; Chen, J.S.; Hanf, D.P.; Chang, M.N.; Chiang, P.Y.C.; Chabala, J.C.; Alberts, A.W.
    The inhibition of cytoplasmic acetoacetyl-CoA thiolase by a triyne carbonate (L-660, 631) (1989), Biochem. Biophys. Res. Commun., 163, 548-553.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.9 2-Oxo-5-(1-hydroxy-2,4,6-heptatriynyl)-1,3-dioxolone-4-heptanoic acid natural product isolated from actinomycete culture L-660,631, IC50: 0.00001 mM, Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.9 cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA Rattus norvegicus
-
acetyl-CoA + acetyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.9 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.9 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.9 CoA + acetoacetyl-CoA
-
Rattus norvegicus acetyl-CoA + acetyl-CoA
-
?
2.3.1.9 CoA + acetoacetyl-CoA
-
Rattus norvegicus acetyl-CoA + acetyl-CoA
-
r

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.9 0.00001
-
natural product isolated from actinomycete culture L-660,631, IC50: 0.00001 mM, Rattus norvegicus 2-Oxo-5-(1-hydroxy-2,4,6-heptatriynyl)-1,3-dioxolone-4-heptanoic acid