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Literature summary extracted from

  • McCarthy, A.D.; Hardie, D.G.
    The multifunctional polypeptide chains of rabbit-mammary fatty-acid synthase. Stoichiometry of active sites and active-site mapping using limited proteolysis (1983), Eur. J. Biochem., 130, 185-193.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 1,3-Dibromo-2-propanone acetyl-CoA, not malonyl-CoA, protects against inactivation, both protect against cross-linking of the subunits Oryctolagus cuniculus
2.3.1.85 chloroacetyl-CoA
-
Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.85 additional information
-
molecular weight of fragments after proteolytic cleavage Oryctolagus cuniculus
2.3.1.85 250000
-
2 * 250000, SDS-PAGE Oryctolagus cuniculus

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
2.3.1.85 acetonitrile up to 10% v/v, stable to Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Oryctolagus cuniculus
-
female
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.85
-
Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.85 mammary gland lactating Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
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Subunits

EC Number Subunits Comment Organism
2.3.1.85 dimer 2 * 250000, SDS-PAGE Oryctolagus cuniculus
2.3.1.85 More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.85 4'-phosphopantetheine location of active site Oryctolagus cuniculus
2.3.1.85 4'-phosphopantetheine present in substoichiometric amounts Oryctolagus cuniculus