Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Meikle, P.J.; Whittle, A.M.; Hopwood, J.J.
    Human acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase. Kinetic characterization and mechanistic interpretation (1995), Biochem. J., 308, 327-333.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.78 coenzyme A noncompetitive Homo sapiens
2.3.1.78 desulfo-CoA competitive against acetyl-CoA Homo sapiens
2.3.1.78 N-acetyl-beta-D-glucosamine competitive against glucosamine; noncompetitive against acetyl-CoA Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.78 0.0025
-
 acetyl-CoA pH 7.0 Homo sapiens
2.3.1.78 0.003
-
 beta-D-glucosamine pH 7.0 Homo sapiens
2.3.1.78 0.054
-
 acetyl-CoA pH 5.0 Homo sapiens
2.3.1.78 0.37
-
 beta-D-glucosamine pH 5.0 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.78 lysosome integral membrane protein Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide Homo sapiens
-
 CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.78 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.78 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.78 placenta
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.78 0.000673
-
 lysosomal fraction Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.78 acetyl-CoA + beta-D-glucosamine
-
 Homo sapiens CoA + N-acetyl-beta-D-glucosamine
-
 ?
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
 Homo sapiens CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
 ?
2.3.1.78 acetyl-CoA + heparin alpha-D-glucosaminide also acetylates di- and tetrasaccharide fragments of heparin Homo sapiens CoA + heparin N-acetyl-D-glucosamine
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.78 additional information
-
-
 Homo sapiens
2.3.1.78 6.5
-
 tetrasaccharide substrate Homo sapiens
2.3.1.78 6.5 8 mono-and disaccharide substrates Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.78 0.032
-
 coenzyme A versus acetyl-CoA Homo sapiens
2.3.1.78 0.082
-
 coenzyme A versus beta-D-glucosamine Homo sapiens
2.3.1.78 0.21
-
 desulfo-CoA versus beta-D-glucosamine Homo sapiens
2.3.1.78 0.22
-
 desulfo-CoA versus acetyl-CoA Homo sapiens
2.3.1.78 3.8
-
 N-acetyl-beta-D-glucosamine versus acetyl-CoA Homo sapiens
2.3.1.78 5.6
-
 N-acetyl-beta-D-glucosamine versus glucosamine Homo sapiens