Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bame, K.J.; Rome, L.H.
    Acetyl-coenzyme A:alpha-glucosaminide N-acetyltransferase. Evidence for an active site histidine residue (1986), J. Biol. Chem., 261, 10127-10132.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.78 diethyl dicarbonate reversible by incubation with hydroxylamine, binds a histidine residue at the active site Rattus norvegicus
2.3.1.78 additional information iodoacetamide and N-ethylmaleimide are not inhibitory Rattus norvegicus
2.3.1.78 N-bromosuccinimide binds a histidine residue at the active site Rattus norvegicus
2.3.1.78 p-chloromercuribenzoate binding site is not the active site Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.78 lysosome enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide Rattus norvegicus
-
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
2.3.1.78 additional information Rattus norvegicus enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.78 Rattus norvegicus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide transmembranal reaction mechanism Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.78 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide
-
Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
2.3.1.78 acetyl-CoA + heparan sulfate alpha-D-glucosaminide brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed Rattus norvegicus CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide
-
?
2.3.1.78 additional information enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate Rattus norvegicus ?
-
?