EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.78 | diethyl dicarbonate | reversible by incubation with hydroxylamine, binds a histidine residue at the active site | Rattus norvegicus | |
2.3.1.78 | additional information | iodoacetamide and N-ethylmaleimide are not inhibitory | Rattus norvegicus | |
2.3.1.78 | N-bromosuccinimide | binds a histidine residue at the active site | Rattus norvegicus | |
2.3.1.78 | p-chloromercuribenzoate | binding site is not the active site | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.78 | lysosome | enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate | Rattus norvegicus | 5764 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.78 | acetyl-CoA + heparan sulfate alpha-D-glucosaminide | Rattus norvegicus | - |
CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
2.3.1.78 | additional information | Rattus norvegicus | enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.78 | Rattus norvegicus | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.1.78 | acetyl-CoA + heparan sulfate alpha-D-glucosaminide = CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | transmembranal reaction mechanism | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.78 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.78 | acetyl-CoA + heparan sulfate alpha-D-glucosaminide | - |
Rattus norvegicus | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
2.3.1.78 | acetyl-CoA + heparan sulfate alpha-D-glucosaminide | brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed | Rattus norvegicus | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? | |
2.3.1.78 | additional information | enzyme is acetylated at the cytoplasmic side of the lysosome and the acetyl group is then transferred to the inside where it is used to acetylate heparan sulfate | Rattus norvegicus | ? | - |
? |