Literature summary extracted from

Jurukovski, V.; Simon, M.
Reduced lecithin:retinol acyl transferase activity in cultured squamous cell carcinoma lines results in increased substrate-driven retinoic acid synthesis (1999), Biochim. Biophys. Acta, 1436, 479-490.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.3.1.76	additional information	not enhanced by retinoic acids	Homo sapiens

Application

EC Number	Application	Comment	Organism
2.3.1.76	medicine	keratinocyte growth and differentiation	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
2.3.1.76	microsome	membrane fraction	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.1.76	acyl-CoA + retinol	Homo sapiens	-	CoA + retinyl ester	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.76	Homo sapiens	-	cell cultures	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.3.1.76	partial purification by differential centrifugation	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.76	carcinoma cell	squamous SCC12b and SCC13b lines are common type of skin cancer that has reduced capacity to esterify retinol relative to normal keratinocytes	Homo sapiens	-
2.3.1.76	keratinocyte	D033 line	Homo sapiens	-

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.3.1.76	additional information	-	activity determined from microsomes	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.76	acyl-CoA + retinol	-	Homo sapiens	CoA + retinyl ester	-	?
2.3.1.76	oleoyl-CoA + retinol	-	Homo sapiens	CoA + retinyloleolate	-	?
2.3.1.76	palmitoyl-CoA + retinol	-	Homo sapiens	CoA + retinylpalmitate	-	?

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Release 2023.1 (January 2023)