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Literature summary extracted from

  • Jogl, G.; Tong, L.
    Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport (2003), Cell, 112, 113-122.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.7 medicine dysregulation of the enzyme can lead to serious diseases in humans, inherited deficiency in CRAT activity can lead to neurological and heart problems, patients suffering from Alzheimer 's disease also have reduced CRAT activity, promising target for therapeutic development against several human diseases like diabetes Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.7
-
Mus musculus
2.3.1.7
-
Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.7 sitting drop vapor diffusion method, space group C2, cell dimensions for the free enzyme crystal a: 158.9 A, b: 89.6 A, c: 119.4 A, beta: 127.5° Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Mus musculus
-
O-acetylcarnitine + CoASH
-
r
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
O-acetylcarnitine + CoASH
-
r
2.3.1.7 acyl-CoA + carnitine Mus musculus
-
acylcarnitine + CoASH
-
r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
acylcarnitine + CoASH
-
r
2.3.1.7 acylcarnitine + CoASH Mus musculus
-
acyl-CoA + carnitine
-
r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
acyl-CoA + carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH Mus musculus
-
acetyl-CoA + carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
acetyl-CoA + carnitine
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Homo sapiens
-
human
-
2.3.1.7 Mus musculus
-
mouse
-
2.3.1.7 Mus musculus P47934 mouse, Protein Data Bank accession number
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
Mus musculus O-acetylcarnitine + CoASH
-
r
2.3.1.7 acetyl-CoA + carnitine
-
Homo sapiens O-acetylcarnitine + CoASH
-
r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
Mus musculus O-acetylcarnitine + CoASH
-
r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
Homo sapiens O-acetylcarnitine + CoASH
-
r
2.3.1.7 acyl-CoA + carnitine
-
Mus musculus acylcarnitine + CoASH
-
r
2.3.1.7 acyl-CoA + carnitine
-
Homo sapiens acylcarnitine + CoASH
-
r
2.3.1.7 acylcarnitine + CoASH
-
Mus musculus acyl-CoA + carnitine
-
r
2.3.1.7 acylcarnitine + CoASH
-
Homo sapiens acyl-CoA + carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH
-
Mus musculus acetyl-CoA + L-(-)carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH
-
Homo sapiens acetyl-CoA + L-(-)carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH
-
Mus musculus acetyl-CoA + carnitine
-
r
2.3.1.7 O-acetylcarnitine + CoASH
-
Homo sapiens acetyl-CoA + carnitine
-
r

Subunits

EC Number Subunits Comment Organism
2.3.1.7 monomer
-
Mus musculus
2.3.1.7 monomer
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CAT
-
Mus musculus
2.3.1.7 CAT
-
Homo sapiens
2.3.1.7 CRAT
-
Mus musculus