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Literature summary extracted from

  • Sheridan, R.; Ratledge, C.
    Changes in cell morphology and carnitine acetyltransferase activity in Candida albicans following growth on lipids and serum and after in vivo incubation in mice (1996), Microbiology, 142, 3171-3180.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.014
-
 acetyl-CoA peroxisomal enzyme Candida albicans
2.3.1.7 0.021
-
 acetyl-CoA
-
 Homo sapiens
2.3.1.7 0.028
-
 propionyl-CoA
-
 Homo sapiens
2.3.1.7 0.034
-
 propionyl-CoA peroxisomal enzyme Candida albicans
2.3.1.7 0.036
-
 acetyl-CoA mitochondrial enzyme Candida tropicalis
2.3.1.7 0.038
-
 acetyl-CoA mitochondrial enzyme Candida albicans
2.3.1.7 0.042
-
 acetyl-CoA peroxisomal enzyme Candida tropicalis
2.3.1.7 0.1
-
 propionyl-CoA peroxisomal enzyme Candida tropicalis
2.3.1.7 0.162
-
 propionyl-CoA mitochondrial enzyme Candida tropicalis
2.3.1.7 0.185
-
 propionyl-CoA mitochondrial enzyme Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion
-
 Homo sapiens 5739
-
2.3.1.7 mitochondrion
-
 Candida albicans 5739
-
2.3.1.7 mitochondrion
-
 Candida tropicalis 5739
-
2.3.1.7 peroxisome
-
 Homo sapiens 5777
-
2.3.1.7 peroxisome
-
 Candida albicans 5777
-
2.3.1.7 peroxisome
-
 Candida tropicalis 5777
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Homo sapiens
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Candida albicans
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Candida tropicalis
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Homo sapiens
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Candida albicans
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Candida tropicalis
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Homo sapiens
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Candida albicans
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Candida tropicalis
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Homo sapiens
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Candida tropicalis
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Candida albicans key enzyme for the translocation of acetyl units between intracellular compartments acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Candida albicans
-
 dimorphic yeast, C316
-
2.3.1.7 Candida tropicalis
-
 yeast
-
2.3.1.7 Candida tropicalis
-
 (Castellani) Berkhout strain pK233(ATCC 20336)
-
2.3.1.7 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Homo sapiens
2.3.1.7
-
 Candida tropicalis
2.3.1.7 partially Candida albicans

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.7 0.002
-
 carbon source glucose, peroxisomal enzyme Candida albicans
2.3.1.7 0.04
-
 carbon source serum, peroxisomal enzyme Candida albicans
2.3.1.7 0.06
-
 carbon source glucose, mitochondrial enzyme Candida albicans
2.3.1.7 0.27
-
 carbon source serum, mitochondrial enzyme Candida albicans
2.3.1.7 4.5
-
 carbon source triolein, mitochondrial enzyme Candida albicans
2.3.1.7 8.8
-
 carbon source triolein, peroxisomal enzyme Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Candida albicans O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Homo sapiens O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Candida albicans O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Candida tropicalis O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Homo sapiens acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Candida albicans acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Candida tropicalis acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Homo sapiens acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Candida albicans acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Candida tropicalis acyl-CoA + carnitine
-
 r
2.3.1.7 additional information octanoyl-CoA and palmitoyl-CoA are no substrates Candida albicans ?
-
 ?
2.3.1.7 additional information octanoyl-CoA and palmitoyl-CoA are no substrates Candida tropicalis ?
-
 ?
2.3.1.7 n-butyryl-CoA + carnitine
-
 Homo sapiens n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyryl-CoA + carnitine
-
 Candida albicans n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyryl-CoA + carnitine
-
 Candida tropicalis n-butyrylcarnitine + CoASH
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Homo sapiens n-butyryl-CoA + carnitine
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Candida albicans n-butyryl-CoA + carnitine
-
 r
2.3.1.7 n-butyrylcarnitine + CoASH
-
 Candida tropicalis n-butyryl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida albicans acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Homo sapiens acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Candida tropicalis acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH key enzyme for the translocation of acetyl units between intracellular compartments Candida albicans acetyl-CoA + carnitine
-
 r
2.3.1.7 octanoyl-CoA + carnitine
-
 Homo sapiens octanoylcarnitine + CoASH
-
 r
2.3.1.7 octanoylcarnitine + CoASH
-
 Homo sapiens octanoyl-CoA + carnitine
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Homo sapiens propionylcarnitine + CoASH
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Candida albicans propionylcarnitine + CoASH
-
 r
2.3.1.7 propionyl-CoA + L-(-)carnitine
-
 Candida tropicalis propionylcarnitine + CoASH
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Homo sapiens propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Candida albicans propionyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 propionylcarnitine + CoASH
-
 Candida tropicalis propionyl-CoA + L-(-)carnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CAT
-
 Homo sapiens
2.3.1.7 CAT
-
 Candida albicans
2.3.1.7 CAT
-
 Candida tropicalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.7 7.5 7.8 peroxisomal enzyme Candida albicans
2.3.1.7 7.5 7.8 peroxisomal enzyme Candida tropicalis
2.3.1.7 8
-
-
 Candida tropicalis
2.3.1.7 8
-
 mitochondrial enzyme Candida albicans