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Literature summary extracted from

  • Gandour, R.D.; Colucci, W.J.; Stelly, T.C.; Brady, P.S.; Brady, L.J.
    Active-site probes of carnitineacyltransferases. Inhibition of carnitine acetyltransferase by hemiacetylcarnitinium, a reaction intermediate analogue (1986), Biochem. Biophys. Res. Commun., 138, 735-741.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.7 Clofibrate enzyme is induced by Rattus norvegicus
2.3.1.7 diethylhexylphthalate enzyme is induced by Rattus norvegicus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.7
-
 Columba sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 (2R,6S:2S,6R)-6-carboxymethyl-2-hydroxy-2,4,4-trimethylmorpholinium chloride hemiacetylcarnitinium Columba sp.
2.3.1.7 (2R,6S:2S,6R)-6-carboxymethyl-2-hydroxy-2,4,4-trimethylmorpholinium chloride hemiacetylcarnitinium Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.7 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Rattus norvegicus
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine Columba sp.
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Rattus norvegicus
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Columba sp.
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Rattus norvegicus
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH Columba sp.
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Rattus norvegicus
-
 acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Columba sp.
-
 acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Columba sp.
-
 pigeon
-
2.3.1.7 Columba sp.
-
 commercial preparation, Sigma
-
2.3.1.7 Rattus norvegicus
-
 rat
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7
-
 Columba sp.

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 breast muscle
-
 Columba sp.
-
2.3.1.7 liver
-
 Rattus norvegicus
-
2.3.1.7 liver
-
 Columba sp.
-
2.3.1.7 muscle
-
 Rattus norvegicus
-
2.3.1.7 muscle
-
 Columba sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Rattus norvegicus O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Columba sp. O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Rattus norvegicus acylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Columba sp. acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Rattus norvegicus acyl-CoA + carnitine
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Columba sp. acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Rattus norvegicus acetyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Columba sp. acetyl-CoA + carnitine
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.7 CAT
-
 Rattus norvegicus
2.3.1.7 CAT
-
 Columba sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.7 0.89
-
 (2R,6S:2S,6R)-6-carboxymethyl-2-hydroxy-2,4,4-trimethylmorpholinium chloride
-
 Columba sp.
2.3.1.7 4.72
-
 (2R,6S:2S,6R)-6-carboxymethyl-2-hydroxy-2,4,4-trimethylmorpholinium chloride
-
 Rattus norvegicus