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Literature summary extracted from

  • Fritz, I.B.; Schultz, S.K.
    Carnitine acetyltransferase. II. Inhibition by carnitine analogues and by sulfhydryl reagents (1965), J. Biol. Chem., 240, 2188-2192.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.7 (+)-acetylcarnitine competitive inhibition Sus scrofa
2.3.1.7 (+)-carnitine
-
 Sus scrofa
2.3.1.7 (-)-acetylcarnitine noncompetitive inhibition Sus scrofa
2.3.1.7 5,5'-dithio-bis(2-nitrobenzoic acid)
-
 Sus scrofa
2.3.1.7 acetylcarnitine
-
 Sus scrofa
2.3.1.7 carnitine nitrile
-
 Sus scrofa
2.3.1.7 choline
-
 Sus scrofa
2.3.1.7 deoxycarnitine competitive inhibition Sus scrofa
2.3.1.7 DL-acetyl-beta-methylcholine
-
 Sus scrofa
2.3.1.7 DL-acetylcarnitine competitive inhibition Sus scrofa
2.3.1.7 DL-carnitine
-
 Sus scrofa
2.3.1.7 gamma-aminobutyrate
-
 Sus scrofa
2.3.1.7 HgCl2
-
 Sus scrofa
2.3.1.7 iodoacetamide
-
 Sus scrofa
2.3.1.7 N-ethylmaleimide
-
 Sus scrofa
2.3.1.7 p-hydroxymercuribenzoate
-
 Sus scrofa
2.3.1.7 Prostigmine
-
 Sus scrofa
2.3.1.7 tensilon
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.7 0.041
-
 CoASH
-
 Sus scrofa
2.3.1.7 0.31
-
 (-)carnitine
-
 Sus scrofa
2.3.1.7 1.6
-
 (-)-norcarnitine
-
 Sus scrofa
2.3.1.7 3.2
-
 DL-norcarnitine
-
 Sus scrofa
2.3.1.7 40
-
 DL-beta-hydroxy-gamma-aminobutyrate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.7 acetyl-CoA + carnitine Sus scrofa
-
 O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine Sus scrofa
-
 acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH Sus scrofa
-
 acyl-CoA + carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH Sus scrofa
-
 acetyl-CoA + carnitine
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.7 Sus scrofa
-
 pig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.7 partially Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.7 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.7 acetyl-CoA + (-)-norcarnitine beta-hydroxy-gamma-dimethylaminobutyrate Sus scrofa acetylnorcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + DL-beta-hydroxy-gamma-aminobutyrate non-methylated derivative of carnitine Sus scrofa beta-hydroxybutyrate + CoASH
-
 r
2.3.1.7 acetyl-CoA + DL-norcarnitine beta-hydroxy-gamma-dimethylaminobutyrate Sus scrofa acetylnorcarnitine + CoASH
-
 r
2.3.1.7 acetyl-CoA + L-(-)carnitine
-
 Sus scrofa O-acetylcarnitine + CoASH
-
 r
2.3.1.7 acyl-CoA + carnitine
-
 Sus scrofa acylcarnitine + CoASH
-
 r
2.3.1.7 acylcarnitine + CoASH
-
 Sus scrofa acyl-CoA + carnitine
-
 r
2.3.1.7 additional information only (-) optical isomers are substrates, unnatural (+) isomers are competitive inhibitors Sus scrofa ?
-
 ?
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + L-(-)carnitine
-
 r
2.3.1.7 O-acetylcarnitine + CoASH
-
 Sus scrofa acetyl-CoA + carnitine
-
 r

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.7 0.25
-
 (+)-acetylcarnitine
-
 Sus scrofa
2.3.1.7 0.39
-
 DL-acetylcarnitine
-
 Sus scrofa
2.3.1.7 0.62
-
 DL-carnitine
-
 Sus scrofa
2.3.1.7 1.2
-
 deoxynorcarnitine
-
 Sus scrofa
2.3.1.7 2.1
-
 (+)carnitine
-
 Sus scrofa
2.3.1.7 2.3
-
 deoxycarnitine
-
 Sus scrofa
2.3.1.7 12
-
 Prostigmine
-
 Sus scrofa
2.3.1.7 15
-
 tensilon
-
 Sus scrofa
2.3.1.7 27
-
 choline
-
 Sus scrofa
2.3.1.7 44
-
 gamma-aminobutyrate
-
 Sus scrofa
2.3.1.7 71
-
 DL-acetyl-beta-methylcholine
-
 Sus scrofa