BRENDA - Enzyme Database

Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid

Garcia, C.; Montero, M.; Alvarez, J.; Sanchez Crespo, M.; J. Biol. Chem. 268, 4001-4008 (1993)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.67
N-formyl-methionyl-leucyl-phenylalanine
stimulation is dependent on the preincubation of cells with cytochalasin B, addition of tumor necrosis factor increases 50% alkyl-2-acetyl-sn-glycero-3-phosphocholine production
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.67
phosphatidic acid
-
Homo sapiens
2.3.1.67
propanolol
-
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.3.1.67
Homo sapiens
-
-
-
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.67
7.5
-
assay at
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.3.1.67
N-formyl-methionyl-leucyl-phenylalanine
stimulation is dependent on the preincubation of cells with cytochalasin B, addition of tumor necrosis factor increases 50% alkyl-2-acetyl-sn-glycero-3-phosphocholine production
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.3.1.67
phosphatidic acid
-
Homo sapiens
2.3.1.67
propanolol
-
Homo sapiens
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.3.1.67
7.5
-
assay at
Homo sapiens