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Literature summary extracted from

  • Dobransky, T.; Davis, W.L.; Rylett, R.J.
    Functional characterization of phosphorylation of 69-kDa human choline acetyltransferase at serine 440 by protein kinase C (2001), J. Biol. Chem., 276, 22244-22250.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.6 expression of wild-type- and S440A mutant-enzyme in HEK293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.6 S440A the wild-type enzyme is distributed predominantly in cytoplasm (88%), with the remainder (12%) bound to cellular membranes, mutation S440A results in localization of the enzyme entirely in cytoplasm Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.6 membrane
-
 Homo sapiens 16020
-
2.3.1.6 membrane
-
 Rattus norvegicus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Homo sapiens
-
-
-
2.3.1.6 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.6 phosphoprotein
-
 Rattus norvegicus
2.3.1.6 phosphoprotein serine 440 of the recombinant human 69-kDa protein is the phoshorylation site Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Homo sapiens acetylcholine + CoA
-
 ?
2.3.1.6 acetyl-CoA + choline
-
 Rattus norvegicus acetylcholine + CoA
-
 ?