Literature summary extracted from

Potempska, A.; Loo, Y.H.; Wisniewski, M.M.
On the possible mechanism of phenylacetate neurotoxicity: inhibition of choline acetyltransferase by phenylacetyl-CoA (1984), J. Neurochem., 42, 1499-1501.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.6	phenylacetate	-	Homo sapiens
2.3.1.6	phenylacetyl-CoA	-	Homo sapiens
2.3.1.6	phenylbutyrate	-	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.3.1.6	0.055	-	acetyl-CoA	-	Homo sapiens
2.3.1.6	4.4	-	choline	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.6	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.6	placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.6	acetyl-CoA + choline	-	Homo sapiens	acetylcholine + CoA	-	?

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
2.3.1.6	0.00031	-	phenylacetyl-CoA	-	Homo sapiens

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Release 2023.1 (January 2023)