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Literature summary extracted from

  • Turchanowa, L.; Dauletbaev, N.; Milovic, V.; Stein, J.
    Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells (2001), Eur. J. Clin. Invest., 31, 887-893.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 additional information indomethacin and excess polyamines induce SSAT activity Homo sapiens

Application

EC Number Application Comment Organism
2.3.1.57 medicine logical target for tumor prevention Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Homo sapiens catabolism of spermidine and spermine CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine Homo sapiens catabolism of spermidine and spermine CoA + N1-acetylspermine
-
 ?
2.3.1.57 additional information Homo sapiens stress-induced enzyme ?
-
 ?
2.3.1.57 additional information Homo sapiens polyamine catabolic enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 Caco-2 cell colon cancer cells Caco-2 and HTC-116 Homo sapiens
-
2.3.1.57 HTC-116 cell colon cancer cells Caco-2 and HTC-116 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine N1-acetylspermidine is the major product ?
2.3.1.57 acetyl-CoA + spermidine catabolism of spermidine and spermine Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermine catabolism of spermidine and spermine Homo sapiens CoA + N1-acetylspermine
-
 ?
2.3.1.57 additional information stress-induced enzyme Homo sapiens ?
-
 ?
2.3.1.57 additional information polyamine catabolic enzyme Homo sapiens ?
-
 ?