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Literature summary extracted from

  • Gerner, E.W.; Kurtts, T.A.; Fuller, D.J.M.; Casero, R.A., Jr.
    Stress induction of the spermidine/spermine N1-acetyltransferase by a post-transcriptional mechanism in mammalian cells (1993), Biochem. J., 294, 491-495.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 additional information certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction Cricetulus griseus
2.3.1.57 additional information certain stresses induce enzyme by a spermidine-dependent post-transcriptional mechanism, e.g. heat shock, diethyldithiocarbamate and high levels of endogenous spermidine, alpha-difluoromethylornithine inhibits stress induction Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.57 6,6-difluorospermidine weak inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 additional information Cricetulus griseus first enzyme in polyamine catabolism ?
-
 ?
2.3.1.57 additional information Homo sapiens first enzyme in polyamine catabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Cricetulus griseus
-
-
-
2.3.1.57 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 A-549 cell lung-cancer derived cells Homo sapiens
-
2.3.1.57 CHO cell
-
 Cricetulus griseus
-
2.3.1.57 melanoma cell line melanoma-derived cells C8146C Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + 6,6-difluorospermidine 16.6% of the rate with spermidine Homo sapiens CoA + N1-acetyl-6,6-difluorospermidine
-
 ?
2.3.1.57 acetyl-CoA + 7,7-difluorospermidine 19.7% of the rate with spermidine Homo sapiens CoA + N1-acetyl-7,7-difluorospermidine
-
 ?
2.3.1.57 acetyl-CoA + spermidine
-
 Cricetulus griseus CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Cricetulus griseus CoA + N1-acetylspermine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
2.3.1.57 additional information first enzyme in polyamine catabolism Cricetulus griseus ?
-
 ?
2.3.1.57 additional information first enzyme in polyamine catabolism Homo sapiens ?
-
 ?