Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ignatenko, N.A.; Fish, J.L.; Shassetz, L.R.; Woolridge, D.P.; Gerner, E.W.
    Expression of the human spermidine/spermine N1-acetyltransferase in spermidine acetylation-deficient Escherichia coli (1996), Biochem. J., 319, 435-440.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 additional information enzyme is induced by isopropyl beta-D-thiogalactopyranoside Homo sapiens

Application

EC Number Application Comment Organism
2.3.1.57 medicine the ability of polyamine analogues to induce N1SSAT activity correlates with the ability to inhibit growth and viability of human tumor-derived cells Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.57 cloning and conditional expression of cDNA encoding enzyme in Escherichia coli CAG2242 results in a decrease of endogenous spermidine contents and growth rates Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine Homo sapiens spermidine acetylation might be a strategy for inhibiting growth in response to environmental stresses CoA + N1-acetylspermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
 recombinant enzyme, expressed in Escherichia coli CAG2242
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine product is exclusively N1-acetylspermidine ?
2.3.1.57 acetyl-CoA + spermidine spermidine acetylation might be a strategy for inhibiting growth in response to environmental stresses Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?