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Literature summary extracted from

  • Quick, D.M.; Wallace, H.M.
    Induction of spermidine/spermine N1-acetyltransferase in human breast carcinoma cells. A possible role for calcium (1993), Biochem. Pharmacol., 46, 969-974.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.57 additional information enzyme is induced by methylglyoxal bis(guanylhydrazone), potentiated by tetronasin or felodipine, tetronasin is also an active inducer, induction is related to the concentration of intracellular free calcium Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.57 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.57 additional information Homo sapiens rate-limiting enzyme in the degradation and interconversion of polyamines ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.57 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.57 T47D cell human breast carcinoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.57 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.57 acetyl-CoA + spermidine
-
 Homo sapiens CoA + N1-acetylspermidine
-
 ?
2.3.1.57 acetyl-CoA + spermine
-
 Homo sapiens CoA + N1-acetylspermine
-
 ?
2.3.1.57 additional information rate-limiting enzyme in the degradation and interconversion of polyamines Homo sapiens ?
-
 ?