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Literature summary extracted from

  • Aguado, B.; Campbell, R.D.
    Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex (1998), J. Biol. Chem., 273, 4096-4105.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.51 expression in insect and mammalian cell lines. The enzyme gene is located in the MHC class III region Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.51 endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.51 Homo sapiens Q99943
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.51 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 acyl-CoA + 1-oleoyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 2-acyl-1-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 arachidonoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 arachidoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-arachidoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 lauroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-lauroyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 lignoceroyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-lignoceroyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 linolenoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-linolenoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 linoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-linoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 additional information the enzyme has affinity for fatty acids of acyl chain lengths from 12 to 18 carbons with a slight dependence on the degree of saturation of the fatty acid. However the enzyme does not incorporate long chain fatty acids like C20:0 and C24:0 unless they are saturated Homo sapiens ?
-
 ?
2.3.1.51 myristoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-myristoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 oleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-oleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 palmitoleoyl-CoA + 1-acyl-sn-glycerol 3-phosphate palmitoleoyl-CoA is a good substrate Homo sapiens CoA + 1-acyl-2-palmitoleoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 palmitoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-palmitoyl-sn-glycerol 3-phosphate
-
 ?
2.3.1.51 stearoyl-CoA + 1-acyl-sn-glycerol 3-phosphate
-
 Homo sapiens CoA + 1-acyl-2-stearoyl-sn-glycerol 3-phosphate
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.51 7.4
-
 assay at Homo sapiens