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Literature summary extracted from

  • Holleran, W.M.; Williams, M.L.; Gao, W.N.; Elias, P.M.
    Serine-palmitoyl transferase activity in cultured human keratinocytes (1990), J. Lipid Res., 31, 1655-1661.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.50 beta-chloro-L-alanine
-
 Homo sapiens
2.3.1.50 L-Cycloserine
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.50 0.4
-
 L-serine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.50 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.50 palmitoyl-CoA + L-serine Homo sapiens rate-limiting enzyme in synthesis of sphingolipids CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.50 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.50 keratinocyte neonatal Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.50 0.00027
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.50 additional information increasing the acyl-CoA chain length above C16 by 1 or 2 carbons is less detrimental to activity than similar decrements in chain length Homo sapiens ?
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine palmitoyl-CoA is used in preference to other saturated or unsaturated acyl-CoA substrates Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?
2.3.1.50 palmitoyl-CoA + L-serine rate-limiting enzyme in synthesis of sphingolipids Homo sapiens CoA + 3-dehydro-D-sphinganine + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.50 8.2
-
-
 Homo sapiens