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Literature summary extracted from

  • Hasan, S.; Hottiger, M.O.
    Histone acetyl transferases: a role in DNA repair and DNA replication (2002), J. Mol. Med., 80, 463-474.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone Tetrahymena thermophila
-
CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Homo sapiens involved in chromatin remodeling and DNA repair CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Saccharomyces cerevisiae involved in chromatin remodeling and DNA repair CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Drosophila melanogaster histone H3 is the preferred substrate CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Mus musculus histone H3 is the preferred substrate CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Homo sapiens histone H3 is the preferred substrate CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Saccharomyces cerevisiae histone H3 is the preferred substrate CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Arabidopsis thaliana histone H3 is the preferred substrate CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Homo sapiens GCN5 involved in chromatin remodeling and DNA repair CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone Homo sapiens GCN5 histone H3 is the preferred substrate CoA + acetylhistone
-
r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Arabidopsis thaliana
-
gene Gcn5
-
2.3.1.48 Drosophila melanogaster
-
gene Gcn5
-
2.3.1.48 Homo sapiens
-
GCN5
-
2.3.1.48 Homo sapiens
-
PCAF protein
-
2.3.1.48 Homo sapiens GCN5
-
GCN5
-
2.3.1.48 Mus musculus
-
gene Gcn5
-
2.3.1.48 Saccharomyces cerevisiae
-
gene Gcn5
-
2.3.1.48 Tetrahymena thermophila
-
protein p55
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone
-
Drosophila melanogaster CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Mus musculus CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Homo sapiens CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Saccharomyces cerevisiae CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Arabidopsis thaliana CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Tetrahymena thermophila CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Homo sapiens CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Saccharomyces cerevisiae CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Drosophila melanogaster CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Mus musculus CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Homo sapiens CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Saccharomyces cerevisiae CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Arabidopsis thaliana CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone
-
Homo sapiens GCN5 CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone involved in chromatin remodeling and DNA repair Homo sapiens GCN5 CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone histone H3 is the preferred substrate Homo sapiens GCN5 CoA + acetylhistone
-
r
2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Drosophila melanogaster CoA + acetylhistone H3
-
r
2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Mus musculus CoA + acetylhistone H3
-
r
2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Homo sapiens CoA + acetylhistone H3
-
r
2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Saccharomyces cerevisiae CoA + acetylhistone H3
-
r
2.3.1.48 acetyl-CoA + histone H3 Gcn5 protein: preferred substrate, acetylation at Lys14 Arabidopsis thaliana CoA + acetylhistone H3
-
r
2.3.1.48 acetyl-CoA + histone H4
-
Tetrahymena thermophila CoA + acetylhistone H4
-
r
2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Drosophila melanogaster CoA + acetylhistone H4
-
r
2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Homo sapiens CoA + acetylhistone H4
-
r
2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Saccharomyces cerevisiae CoA + acetylhistone H4
-
r
2.3.1.48 acetyl-CoA + histone H4 Gcn5 protein acetylates H4 when purified and presented separately to the enzyme at Lys8 and Lys16 Arabidopsis thaliana CoA + acetylhistone H4
-
r
2.3.1.48 acetyl-CoA + protein p53
-
Homo sapiens CoA + acetylprotein p53
-
r
2.3.1.48 additional information Gcn5 is a coactivator of transcription Drosophila melanogaster ?
-
?
2.3.1.48 additional information Gcn5 is a coactivator of transcription Mus musculus ?
-
?
2.3.1.48 additional information Gcn5 is a coactivator of transcription Homo sapiens ?
-
?
2.3.1.48 additional information Gcn5 is a coactivator of transcription Saccharomyces cerevisiae ?
-
?
2.3.1.48 additional information Gcn5 is a coactivator of transcription Arabidopsis thaliana ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Drosophila melanogaster ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Mus musculus ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Saccharomyces cerevisiae ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Arabidopsis thaliana ?
-
?
2.3.1.48 additional information Gcn5 is a coactivator of transcription Homo sapiens GCN5 ?
-
?
2.3.1.48 additional information Gcn5 and PCAF protein are transcription cofactors Homo sapiens GCN5 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Drosophila melanogaster
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Mus musculus
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Homo sapiens
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Saccharomyces cerevisiae
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Arabidopsis thaliana
2.3.1.48 factor acetyltransferase enzyme form A is also able to acetylate nonhistone proteins, mostly transcription factors, overview Tetrahymena thermophila
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Drosophila melanogaster
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Mus musculus
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Homo sapiens
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Saccharomyces cerevisiae
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Arabidopsis thaliana
2.3.1.48 FAT when acetylating nonhistone transcription factor proteins, factor specific, overview Tetrahymena thermophila
2.3.1.48 HAT
-
Drosophila melanogaster
2.3.1.48 HAT
-
Homo sapiens
2.3.1.48 HAT
-
Saccharomyces cerevisiae
2.3.1.48 HAT
-
Arabidopsis thaliana
2.3.1.48 HAT
-
Tetrahymena thermophila
2.3.1.48 More type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview Drosophila melanogaster
2.3.1.48 More type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview Homo sapiens
2.3.1.48 More type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview Saccharomyces cerevisiae
2.3.1.48 More type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview Arabidopsis thaliana
2.3.1.48 More type A enzymes can be grouped into different families based on amino acid sequence comparison and binding motifs, overview Tetrahymena thermophila
2.3.1.48 More type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication Drosophila melanogaster
2.3.1.48 More type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication Homo sapiens
2.3.1.48 More type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication Saccharomyces cerevisiae
2.3.1.48 More type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication Arabidopsis thaliana
2.3.1.48 More type A enzymes are localized in the nuclei and acetylate nucleosomal histones as well as nonhistone proteins, type B enzymes can be found in the cytoplasmic fraction and are responsible for acetylation of newly synthesized histones before their translocation into the nucleus for chromatin assembly during DNA replication Tetrahymena thermophila