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Literature summary extracted from

  • Clarke, A.S.; Lowell, J.E.; Jacobson, S.J.; Pillus, L.
    Esa1p is an essential histone acetyltransferase required for cell cycle progression (1999), Mol. Cell. Biol., 19, 2515-2526.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.48 expression of Esa1 gene in Escherichia coli Saccharomyces cerevisiae

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.48 additional information temperature sensitive Esa1 mutant strain shows reduced activity in vitro and needs histone H4 acetylated at Lys5 as substrate in vivo Saccharomyces cerevisiae
2.3.1.48 additional information diverse Esa1 gene mutant strains, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone Saccharomyces cerevisiae Esa1 protein is involved in cell cycle regulation CoA + acetylhistone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Saccharomyces cerevisiae
-
 Esa1 gene
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone
-
 Saccharomyces cerevisiae CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone Esa1 protein is involved in cell cycle regulation Saccharomyces cerevisiae CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone H2A
-
 Saccharomyces cerevisiae CoA + acetylhistone H2A
-
 ?
2.3.1.48 acetyl-CoA + histone H3
-
 Saccharomyces cerevisiae CoA + acetylhistone H3
-
 ?
2.3.1.48 acetyl-CoA + histone H4 histone H4 is the preferred substrate Saccharomyces cerevisiae CoA + acetylhistone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.48 HAT
-
 Saccharomyces cerevisiae
2.3.1.48 More enzymes with histone acetyltransferase and transcription cofactor activity belong to the MYST protein family Saccharomyces cerevisiae