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Literature summary extracted from

  • Wiegand, R.C.; Brutlag, D.L.
    Histone acetylase from Drosophila melanogaster specific for H4 (1981), J. Biol. Chem., 256, 4578-4583.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 Brij-58
-
 Drosophila melanogaster
2.3.1.48 CoA
-
 Drosophila melanogaster
2.3.1.48 DNA dsDNA Drosophila melanogaster
2.3.1.48 histone histones H2A, H2B, and H3 Drosophila melanogaster
2.3.1.48 histone H4
-
 Drosophila melanogaster
2.3.1.48 Nonidet P40
-
 Drosophila melanogaster
2.3.1.48 Polyarginine
-
 Drosophila melanogaster
2.3.1.48 Polyglutamic acid
-
 Drosophila melanogaster
2.3.1.48 polylysine
-
 Drosophila melanogaster
2.3.1.48 potassium phosphate 90 mM Drosophila melanogaster
2.3.1.48 protamine
-
 Drosophila melanogaster
2.3.1.48 RNA
-
 Drosophila melanogaster
2.3.1.48 Triton X-100
-
 Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.48 additional information
-
 additional information
-
 Drosophila melanogaster

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 160000
-
 nondenaturing PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.48 acetyl-CoA + histone Drosophila melanogaster most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly CoA + acetylhistone
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48
-
 Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 embryo
-
 Drosophila melanogaster
-
2.3.1.48 hepatoma cell tissue culture cell, HTC cells Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone
-
 Drosophila melanogaster CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone most likely involved in acetylation of newly synthesized histones in cytoplasm prior to chromatin assembly Drosophila melanogaster CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone H4 highly specific for Drosophila melanogaster CoA + acetylhistone H4
-
 ?
2.3.1.48 acetyl-CoA + histone H4 histone H4: all of the acetate groups are introduced within the NH2-terminal amino acids 4 to 17 Drosophila melanogaster CoA + acetylhistone H4
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.48 60
-
 1 min, irreversible denaturation Drosophila melanogaster

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 9
-
-
 Drosophila melanogaster

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.1.48 6.5
-
 rapid loss of activity below Drosophila melanogaster