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Literature summary extracted from

  • Gallwitz, D.; Sures, I.
    Histone acetylation. Purification and properties of three histone-specific acetyltransferases from rat thymus nuclei (1972), Biochim. Biophys. Acta, 263, 315-328.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.48 N-ethylmaleimide
-
 Rattus norvegicus
2.3.1.48 p-chloromercuribenzoate strongly inhibits activity of enzyme form B, formation of acyl-enzyme complex Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.48 chromatin
-
 Rattus norvegicus 785
-
2.3.1.48 nucleus
-
 Rattus norvegicus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.48 92000
-
 enzyme form B2, gel filtration Rattus norvegicus
2.3.1.48 99000
-
 enzyme form A, gel filtration Rattus norvegicus
2.3.1.48 110000
-
 enzyme form B1, gel filtration Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.48 Rattus norvegicus
-
 3 enzyme forms: A, B1, B2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.48
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.48 thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.48 acetyl-CoA + histone histone f1, enzyme form A Rattus norvegicus CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + histone histone f2a1, enzyme form B1 and B2 Rattus norvegicus CoA + acetylhistone
-
 ?
2.3.1.48 acetyl-CoA + poly-L-lysine enzyme form A, not enzyme form B1 and B2 Rattus norvegicus CoA + N6-acetyllysine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.48 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.48 8.1
-
 enzyme form A Rattus norvegicus
2.3.1.48 8.7
-
 enzyme form B1 and B2 Rattus norvegicus