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Literature summary extracted from

  • Hajra, A.K.
    Dihydroxyacetone phosphate acyltransferase (1997), Biochim. Biophys. Acta, 1348, 27-34.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.42 acetaldehyde
-
 Cavia porcellus
2.3.1.42 Isopropanol stimulation Cavia porcellus
2.3.1.42 additional information heat shock, osmotic shock and freeze-thaw cycles increase enzyme activity Cavia porcellus
2.3.1.42 Phospholipid stimulates partially purified enzyme, not membrane-bound Cavia porcellus

General Stability

EC Number General Stability Organism
2.3.1.42 heat shock, osmotic shock and freeze-thaw cycles increase enzyme activity at pH 7.5, at pH 5.5 activity is decreased Cavia porcellus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.42 5,5'-dithio-bis(2-nitrobenzoate) i.e. DTNB; no inhibition Cavia porcellus
2.3.1.42 5,5'-dithio-bis(2-nitrobenzoate) i.e. DTNB; no inhibition Homo sapiens
2.3.1.42 5,5'-dithio-bis(2-nitrobenzoate) i.e. DTNB; no inhibition Oryctolagus cuniculus
2.3.1.42 5,5'-dithio-bis(2-nitrobenzoate) i.e. DTNB; no inhibition Rattus norvegicus
2.3.1.42 5,5'-dithio-bis(2-nitrobenzoate) i.e. DTNB; no inhibition Saccharomyces cerevisiae
2.3.1.42 Hg2+
-
 Cavia porcellus
2.3.1.42 N-ethylmaleimide no inhibition Cavia porcellus
2.3.1.42 N-ethylmaleimide no inhibition Homo sapiens
2.3.1.42 N-ethylmaleimide no inhibition Oryctolagus cuniculus
2.3.1.42 N-ethylmaleimide no inhibition Rattus norvegicus
2.3.1.42 N-ethylmaleimide no inhibition Saccharomyces cerevisiae
2.3.1.42 Pb2+
-
 Cavia porcellus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.42 additional information
-
 additional information
-
 Cavia porcellus
2.3.1.42 additional information
-
 additional information
-
 Rattus norvegicus
2.3.1.42 0.04 0.06 dihydroxyacetone phosphate low concentration of substrate Cavia porcellus
2.3.1.42 0.2 0.25 dihydroxyacetone phosphate high concentration of substrate Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.42 microsome
-
 Cavia porcellus
-
-
2.3.1.42 microsome
-
 Homo sapiens
-
-
2.3.1.42 microsome
-
 Rattus norvegicus
-
-
2.3.1.42 microsome
-
 Oryctolagus cuniculus
-
-
2.3.1.42 peroxisome membrane-bound Cavia porcellus 5777
-
2.3.1.42 peroxisome membrane-bound Homo sapiens 5777
-
2.3.1.42 peroxisome membrane-bound Rattus norvegicus 5777
-
2.3.1.42 peroxisome membrane-bound Oryctolagus cuniculus 5777
-
2.3.1.42 peroxisome microperoxisome of brain, intestinal mucosa Rattus norvegicus 5777
-
2.3.1.42 peroxisome catalytic site at inner surface of peroxisomal membrane Cavia porcellus 5777
-
2.3.1.42 peroxisome catalytic site at inner surface of peroxisomal membrane Homo sapiens 5777
-
2.3.1.42 peroxisome catalytic site at inner surface of peroxisomal membrane Rattus norvegicus 5777
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.42 Mg2+ stimulation Cavia porcellus
2.3.1.42 additional information
-
 Oryctolagus cuniculus
2.3.1.42 additional information no activation by Mg2+, partially purified Cavia porcellus
2.3.1.42 additional information no activation by Mg2+, partially purified Rattus norvegicus
2.3.1.42 additional information no activation by Mn2+, partially purified Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.42 additional information Homo sapiens enzyme activity is reduced with disorders: neonatal adrenoleukodystrophy, infantile Refsum disease, and hyperpipecolic acidemia ?
-
 ?
2.3.1.42 additional information Homo sapiens enzyme amount is reduced by 90% in Zellweger syndrome ?
-
 ?
2.3.1.42 additional information Homo sapiens patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting ?
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Saccharomyces cerevisiae no precursor for glycerol ether lipids CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Cavia porcellus obligate precursor in ether lipids biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 r
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Homo sapiens obligate precursor in ether lipids biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Rattus norvegicus obligate precursor in ether lipids biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Saccharomyces cerevisiae obligate precursor in ether lipids biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Oryctolagus cuniculus obligate precursor in ether lipids biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Cavia porcellus reaction in phosphatidic acid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 r
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Homo sapiens reaction in phosphatidic acid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Rattus norvegicus reaction in phosphatidic acid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Saccharomyces cerevisiae reaction in phosphatidic acid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate Oryctolagus cuniculus reaction in phosphatidic acid biosynthesis CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.42 Cavia porcellus
-
-
-
2.3.1.42 Homo sapiens
-
-
-
2.3.1.42 no activity in Schizosaccharomyces pombe
-
-
-
2.3.1.42 Oryctolagus cuniculus
-
-
-
2.3.1.42 Rattus norvegicus
-
-
-
2.3.1.42 Saccharomyces cerevisiae
-
-
-
2.3.1.42 Saccharomyces pastorianus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.42
-
 Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.42 adipocyte
-
 Cavia porcellus
-
2.3.1.42 adipocyte
-
 Rattus norvegicus
-
2.3.1.42 brain
-
 Rattus norvegicus
-
2.3.1.42 harderian gland
-
 Oryctolagus cuniculus
-
2.3.1.42 intestine mucosa Rattus norvegicus
-
2.3.1.42 kidney
-
 Cavia porcellus
-
2.3.1.42 kidney
-
 Rattus norvegicus
-
2.3.1.42 liver
-
 Cavia porcellus
-
2.3.1.42 liver
-
 Homo sapiens
-
2.3.1.42 liver
-
 Rattus norvegicus
-
2.3.1.42 liver
-
 Oryctolagus cuniculus
-
2.3.1.42 placenta
-
 Homo sapiens
-
2.3.1.42 skin fibroblast cell culture Homo sapiens
-
2.3.1.42 spleen
-
 Cavia porcellus
-
2.3.1.42 spleen
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.42 additional information
-
 assay methods, overview Cavia porcellus
2.3.1.42 additional information
-
 assay methods, overview Homo sapiens
2.3.1.42 additional information
-
 assay methods, overview Rattus norvegicus
2.3.1.42 additional information
-
 assay methods, overview Saccharomyces cerevisiae
2.3.1.42 additional information
-
 assay methods, overview Oryctolagus cuniculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Cavia porcellus CoA + acyldihydroxyacetone phosphate
-
 r
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Homo sapiens CoA + acyldihydroxyacetone phosphate
-
 ir
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + acyldihydroxyacetone phosphate
-
 ir
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Saccharomyces cerevisiae CoA + acyldihydroxyacetone phosphate
-
 ir
2.3.1.42 acyl-CoA + dihydroxyacetone phosphate
-
 Oryctolagus cuniculus CoA + acyldihydroxyacetone phosphate
-
 ir
2.3.1.42 additional information enzyme activity is reduced with disorders: neonatal adrenoleukodystrophy, infantile Refsum disease, and hyperpipecolic acidemia Homo sapiens ?
-
 ?
2.3.1.42 additional information enzyme amount is reduced by 90% in Zellweger syndrome Homo sapiens ?
-
 ?
2.3.1.42 additional information patients affected with rhizomelic chondrodysplasia punctata show reduced enzyme activity due to a defect in peroxisomal targeting Homo sapiens ?
-
 ?
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Cavia porcellus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Homo sapiens CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Saccharomyces cerevisiae CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate
-
 Oryctolagus cuniculus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate no precursor for glycerol ether lipids Saccharomyces cerevisiae CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate obligate precursor in ether lipids biosynthesis Cavia porcellus CoA + monopalmitoyldihydroxyacetone phosphate
-
 r
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate obligate precursor in ether lipids biosynthesis Homo sapiens CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate obligate precursor in ether lipids biosynthesis Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate obligate precursor in ether lipids biosynthesis Saccharomyces cerevisiae CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate obligate precursor in ether lipids biosynthesis Oryctolagus cuniculus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate reaction in phosphatidic acid biosynthesis Cavia porcellus CoA + monopalmitoyldihydroxyacetone phosphate
-
 r
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate reaction in phosphatidic acid biosynthesis Homo sapiens CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate reaction in phosphatidic acid biosynthesis Rattus norvegicus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate reaction in phosphatidic acid biosynthesis Saccharomyces cerevisiae CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 palmitoyl-CoA + dihydroxyacetone phosphate reaction in phosphatidic acid biosynthesis Oryctolagus cuniculus CoA + monopalmitoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 stearoyl-CoA + dihydroxyacetone phosphate
-
 Cavia porcellus CoA + stearoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 stearoyl-CoA + dihydroxyacetone phosphate
-
 Homo sapiens CoA + stearoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 stearoyl-CoA + dihydroxyacetone phosphate
-
 Rattus norvegicus CoA + stearoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 stearoyl-CoA + dihydroxyacetone phosphate
-
 Saccharomyces cerevisiae CoA + stearoyldihydroxyacetone phosphate
-
 ir
2.3.1.42 stearoyl-CoA + dihydroxyacetone phosphate
-
 Oryctolagus cuniculus CoA + stearoyldihydroxyacetone phosphate
-
 ir

Synonyms

EC Number Synonyms Comment Organism
2.3.1.42 DHAPAT
-
 Cavia porcellus
2.3.1.42 DHAPAT
-
 Homo sapiens
2.3.1.42 DHAPAT
-
 Rattus norvegicus
2.3.1.42 DHAPAT
-
 Saccharomyces cerevisiae
2.3.1.42 DHAPAT
-
 Oryctolagus cuniculus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.3.1.42 additional information
-
 membrane-bound: heat-stable Cavia porcellus
2.3.1.42 additional information
-
 membrane-bound: heat-stable Rattus norvegicus
2.3.1.42 55
-
-
 Rattus norvegicus
2.3.1.42 55
-
 15 min stable, crude peroxisomal preparation Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.42 additional information
-
 overview Cavia porcellus
2.3.1.42 additional information
-
 overview Homo sapiens
2.3.1.42 additional information
-
 overview Rattus norvegicus
2.3.1.42 additional information
-
 overview Saccharomyces cerevisiae
2.3.1.42 additional information
-
 overview Oryctolagus cuniculus