Literature summary extracted from
Price, A.C.; Choi, K.H.; Heath, R.J.; Li, Z.; White, S.W.; Rock, C.O.
Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism (2001), J. Biol. Chem., 276, 6551-6559.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
2.3.1.41 |
synthases I, II, and III, recombinant expression |
Escherichia coli |
Crystallization (Commentary)
EC Number |
Crystallization (Comment) |
Organism |
---|
2.3.1.41 |
structure analysis, three-dimensional model of enzyme complexed with inhibitors thiolactomycin and cerulenin |
Escherichia coli |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
2.3.1.41 |
cerulenin |
analysis of the binding mechanism, mimicks the condensation transition state; FabB: inhibition is irreversible |
Escherichia coli |
|
2.3.1.41 |
thiolactomycin |
analysis of the binding mechanism, mimics malonyl-[acyl-carrier-protein]; FabB: inhibition is reversible, competitive |
Escherichia coli |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.3.1.41 |
Escherichia coli |
- |
synthases I, II, and III |
- |
Purification (Commentary)
EC Number |
Purification (Comment) |
Organism |
---|
2.3.1.41 |
recombinant synthases I, i.e. FabA, II, i.e. FabB, and III, i.e.FabH |
Escherichia coli |
Reaction
EC Number |
Reaction |
Comment |
Organism |
Reaction ID |
---|
2.3.1.41 |
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] |
synthaseIII/FabH: His-Asn-Cys catalytic triad |
Escherichia coli |
|
2.3.1.41 |
an acyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a 3-oxoacyl-[acyl-carrier protein] + CO2 + an [acyl-carrier protein] |
synthaseII/FabB: His-HIs-Cys catalytic triad |
Escherichia coli |
|
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
2.3.1.41 |
saturated acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] |
- |
Escherichia coli |
3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] |
- |
? |
|